{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T20:55:08Z","timestamp":1794171308508,"version":"4.8.0"},"reference-count":19,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"unspecified","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,13]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>One pitfall in 24-hour urine collection is the input of incorrect urinary volume by the reference laboratory. This may lead to an incorrect diagnosis of pheochromocytoma or paraganglioma. A 48-year-old African-American woman was seen in the clinic for an elevated 24-hour urine metanephrine screen during workup for secondary hypertension. Urine volume was found to be incorrectly inputted by the lab as 9750 mL rather than 975 mL. The urinary metanephrines were then recalculated and the 24-hour urinary metanephrines resulted within normal limits. This case highlights this unique and potentially under-recognised error in testing with 24-hour urine volume collection.<\/jats:p>","DOI":"10.1136\/bcr-2020-241147","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T23:58:48Z","timestamp":1612483128000},"page":"e241147","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["False elevations in urinary metanephrines: under-recognised pitfall with 24-hour urinary volume collection"],"prefix":"10.1136","volume":"14","author":[{"given":"Terry","family":"Shin","sequence":"first","affiliation":[{"name":"Endocrinology, Womack Army Medical Center, Fort Bragg, North Carolina, USA"},{"name":"Uniformed Services University of the Health Sciences, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Duc","family":"Hoang","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences, Bethesda, MD, USA"},{"name":"Endocrinology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Thomas","family":"Plunkett","sequence":"additional","affiliation":[{"name":"Endocrinology, Womack Army Medical Center, Fort Bragg, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed K M","family":"Shakir","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences, Bethesda, MD, USA"},{"name":"Endocrinology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"2025082707344414000_14.2.e241147.1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9258(18)65893-4","article-title":"The phenolic acids of human urine; paper chromatography of phenolic acids","volume":"218(1","author":"Armstrong","year":"1956","journal-title":"J Biol Chem"},{"key":"2025082707344414000_14.2.e241147.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"2025082707344414000_14.2.e241147.3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cca.2017.05.002","article-title":"Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS\/MS: impact of gender, age, oral contraceptives, body mass index and blood pressure status","volume":"470","author":"Eisenhofer","year":"2017","journal-title":"Clin Chim Acta"},{"key":"2025082707344414000_14.2.e241147.4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4103\/1947-2714.132941","article-title":"Types and frequency of errors during different phases of testing at a clinical medical laboratory of a teaching hospital in Tehran, Iran","volume":"6","author":"Abdollahi","year":"2014","journal-title":"N Am J Med Sci"},{"key":"2025082707344414000_14.2.e241147.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.03.023"},{"key":"2025082707344414000_14.2.e241147.6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021251"},{"key":"2025082707344414000_14.2.e241147.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02805.x"},{"key":"2025082707344414000_14.2.e241147.8","first-page":"119","article-title":"Accuracy in 24-hour urine collection at a tertiary center","volume":"20","author":"Boyd","year":"2018","journal-title":"Rev Urol"},{"key":"2025082707344414000_14.2.e241147.9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1089\/end.2012.0203","article-title":"Adequate or not? A comparison of 24-hour urine studies for renal stone prevention by creatinine to weight ratio","volume":"27","author":"Sawyer","year":"2013","journal-title":"J Endourol"},{"key":"2025082707344414000_14.2.e241147.10","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1089\/end.2014.0544","article-title":"Predicting patients with inadequate 24- or 48-hour urine collections at time of metabolic stone evaluation","volume":"29","author":"McGuire","year":"2015","journal-title":"J Endourol"},{"key":"2025082707344414000_14.2.e241147.11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.11613\/BM.2013.038","article-title":"Low level of adherence to instructions for 24-hour urine collection among hospital outpatients","volume":"23","author":"Miler","year":"2013","journal-title":"Biochem Med"},{"key":"2025082707344414000_14.2.e241147.12","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2009.272"},{"key":"2025082707344414000_14.2.e241147.13","doi-asserted-by":"publisher","DOI":"10.1177\/014860718701100510"},{"key":"2025082707344414000_14.2.e241147.14","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05030610"},{"key":"2025082707344414000_14.2.e241147.15","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1111\/jch.13696","article-title":"Addressing the problem of inaccuracy of measured 24-hour urine collections due to incomplete collection","volume":"21","author":"Mann","year":"2019","journal-title":"J Clin Hypertens"},{"key":"2025082707344414000_14.2.e241147.16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1530\/EJE-19-1016","article-title":"Overnight\/first-morning urine free metanephrines and methoxytyramine for diagnosis of pheochromocytoma and paraganglioma: is this an option?","volume":"182","author":"Peitzsch","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"2025082707344414000_14.2.e241147.17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.4.1378"},{"key":"2025082707344414000_14.2.e241147.18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-08612-8","article-title":"Direct electrochemical measurement of metanephrines in spot urine samples for the diagnosis of phaeochromocytomas","volume":"7","author":"Shi","year":"2017","journal-title":"Sci Rep"},{"key":"2025082707344414000_14.2.e241147.19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cca.2017.12.026","article-title":"High specificity of spot urinary free metanephrines in diagnosis and prognosis of pheochromocytomas and paragangliomas by HPLC with electrochemical detection","volume":"478","author":"Zuo","year":"2018","journal-title":"Clin Chim Acta"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-241147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:34:54Z","timestamp":1756305294000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-241147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,4]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-241147"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-241147","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}