{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:35:33Z","timestamp":1778272533579,"version":"3.51.4"},"reference-count":17,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,3,22]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Calciphylaxis is commonly associated with end-stage renal disease (ESRD) and renal transplant. We present a rare case of early onset calciphylaxis in a patient presenting with acute kidney injury (AKI) secondary to anti-glomerular basement membrane (anti-GBM) antibody disease. A 65-year-old obese Caucasian woman with type 2 diabetes mellitus and hypertension presented with a 1-month history of painless gross haematuria and worsening lower extremity oedema. Laboratory results indicated AKI and nephrotic-range proteinuria. Anti-glomerular antibodies were elevated. Renal biopsy revealed focal crescentic glomerulonephritis with linear capillary immunoglobulin G staining consistent with anti-GBM antibody disease. She was treated with haemodialysis, plasmapheresis, steroids, bumetanide and cyclophosphamide. Two months later, she developed necrotic lesions on bilateral thighs. Wound biopsy was consistent with calciphylaxis. This case highlights that calciphylaxis, usually seen in patients with chronic kidney disease or ESRD, can manifest in patients with AKI as well.<\/jats:p>","DOI":"10.1136\/bcr-2020-241265","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T13:39:45Z","timestamp":1617802785000},"page":"e241265","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Early onset calciphylaxis following acute kidney injury secondary to anti-glomerular basement membrane antibody disease"],"prefix":"10.1136","volume":"14","author":[{"given":"Sheikh Raza","family":"Shahzad","sequence":"first","affiliation":[{"name":"Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faris","family":"Alfaris","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Albany Medical Center Hospital, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-7421","authenticated-orcid":false,"given":"Mustafa Erdem","family":"Arslan","sequence":"additional","affiliation":[{"name":"Pathology, Albany Medical Center Hospital, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Mehta","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Albany Medical Center Hospital, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"2025082711313193000_14.4.e241265.1","article-title":"A rare case of Calciphylaxis in an orthotopic liver transplant recipient with acute kidney injury","author":"Nseir","year":"2018","journal-title":"Exp Clin Transplant"},{"key":"2025082711313193000_14.4.e241265.2","article-title":"Chronic kidney disease and Calciphylaxis: a literature review","volume":"10","author":"Ahmed","year":"2018","journal-title":"Cureus"},{"key":"2025082711313193000_14.4.e241265.3","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00530108"},{"key":"2025082711313193000_14.4.e241265.4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1590\/abd1806-4841.20132280","article-title":"Calciphylaxis: a rare but potentially fatal event of chronic kidney disease. 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