{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:29:06Z","timestamp":1780565346447,"version":"3.54.1"},"reference-count":8,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,3,31]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>A 74-year-old woman with a history of primary hyperparathyroidism, thyroid nodules, atrial fibrillation and pacemaker placement for sick sinus syndrome presented with fatigue, constipation and persistent lower extremity oedema. She underwent subtotal parathyroidectomy and left thyroid lobectomy. Histopathology revealed amyloidosis affecting the thyroidand parathyroids confirmed by Congo Red Staining with Mayo Clinic subtyping of light chain kappa-type amyloidosis. She was found to have combined systolic and diastolic cardiac dysfunction, carpal tunnel neuropathy and pre-diabetes suggestive of systemic amyloidosis with involvement of the heart, nerves and pancreas. Congo red stain was positive for amyloidosis on bone marrow biopsy suggestive of a diagnosis of systemic amyloidosis. She was treated with daratumumab with good clinical response. This case illustrates the necessity of considering systemic amyloidosis in patients with incidentally discovered diffuse amyloid deposits on biopsy of an endocrine organ, as endocrine effects are a rare but likely underdiagnosed consequence of systemic amyloidosis.<\/jats:p>","DOI":"10.1136\/bcr-2020-241282","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T13:11:33Z","timestamp":1618837893000},"page":"e241282","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Systemic light-chain amyloidosis incidentally diagnosed after subtotal parathyroidectomy and thyroid lobectomy"],"prefix":"10.1136","volume":"14","author":[{"given":"Karen","family":"Tsai","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA"},{"name":"Division of Endocrinology, Diabetes, and Metabolism, UCLA David Geffen School of Medicine, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Chen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masha J","family":"Livhits","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, UCLA David Geffen School of Medicine, Los Angeles, USA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti","family":"Sajed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UCLA Geffen School of Medicine, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, VA Greater 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PET\/CT","volume":"60","author":"Ehman","year":"2019","journal-title":"J Nucl Med"},{"key":"2025082803303822000_14.4.e241282.7","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2482-13-S2-S43","article-title":"Nodular goiter with amyloid deposition in an elderly patient: fine-needle cytology diagnosis and review of the literature","volume":"13 Suppl 2","author":"Di Crescenzo","year":"2013","journal-title":"BMC Surg"},{"key":"2025082803303822000_14.4.e241282.8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1210\/js.2017-00445","article-title":"Rare undiagnosed primary amyloidosis unmasked during surgical treatment of primary hyperparathyroidism: a case report","volume":"2","author":"Gallagher","year":"2018","journal-title":"J Endocr Soc"}],"container-title":["BMJ Case 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