{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:32:05Z","timestamp":1788852725221,"version":"build-2803163510"},"reference-count":23,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,30]]},"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Osteonecrosis of the jaw (ONJ) is necrosis of mandibular or maxillary bone, which sometimes leads to bone exposure and sequestration. There is evidence that the microenvironment of the marrow stromal system is severely and irreversibly damaged after haematopoietic stem cell transplantation (HSCT) leading to a deficit in the quantity and quality of osteoblastic progenitors, compromising the ability to regenerate a normal osteogenic cell population and abnormality in bone remodelling\/turnover. While osteonecrosis of the appendicular skeleton is a common complication after HSCT, there have been no reports of an association with ONJ. This is a report of the first case of ONJ secondary to HSCT in a 69-year-old woman who developed a unique pattern of osteonecrosis involving all four quadrants of the jaw 2\u2009months after allogeneic stem cell transplantation.<\/jats:p>","DOI":"10.1136\/bcr-2020-241298","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T13:35:36Z","timestamp":1614951336000},"page":"e241298","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Osteonecrosis of the jaw secondary to haematopoietic stem cell transplantation"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-6018","authenticated-orcid":false,"given":"Shaiba","family":"Sandhu","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Harvard School of Dental Medicine, Boston, Massachusetts, USA"},{"name":"Brigham and Women's Hospital, Boston, Massachusetts, USA"},{"name":"Dana Farber Cancer Institute, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Sankar","sequence":"additional","affiliation":[{"name":"Tufts University School of Dental Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"2025082709164643000_14.3.e241298.1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2405"},{"key":"2025082709164643000_14.3.e241298.2","first-page":"96","article-title":"Necrosis of the lower jaw in makers of Lucifer matches","volume":"1","year":"1867","journal-title":"Am J Dent Science"},{"key":"2025082709164643000_14.3.e241298.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"2025082709164643000_14.3.e241298.4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.coms.2015.06.008","article-title":"Diagnosis and staging of medication-related osteonecrosis of the jaw","volume":"27","author":"Ruggiero","year":"2015","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"2025082709164643000_14.3.e241298.5","doi-asserted-by":"crossref","unstructured":"Tauchmanov L , De Rosa G , Serio B . Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: a single center experience and a review. Cancer 2003;97.doi:10.1002\/cncr.11373","DOI":"10.1002\/cncr.11373"},{"key":"2025082709164643000_14.3.e241298.6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.seminhematol.2011.10.007","article-title":"Bone loss and avascular necrosis of bone after hematopoietic cell transplantation","volume":"49","author":"McClune","year":"2012","journal-title":"Semin Hematol"},{"key":"2025082709164643000_14.3.e241298.7","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1080\/14740338.2016.1177021","article-title":"Osteonecrosis of jaw beyond antiresorptive (bone-targeted) agents: new horizons in oncology","volume":"15","author":"Fusco","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"2025082709164643000_14.3.e241298.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80047-3"},{"key":"2025082709164643000_14.3.e241298.9","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0280"},{"key":"2025082709164643000_14.3.e241298.10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/idj.12318","article-title":"Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A Concise review","volume":"68","author":"Chronopoulos","year":"2018","journal-title":"Int Dent J"},{"key":"2025082709164643000_14.3.e241298.11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2169\/internalmedicine.8946-17","article-title":"Oral methotrexate-related lymphoproliferative disease presenting with severe osteonecrosis of the jaw: a case report and literature review","volume":"57","author":"Furukawa","year":"2018","journal-title":"Intern Med"},{"key":"2025082709164643000_14.3.e241298.12","doi-asserted-by":"crossref","unstructured":"Wong LS , Tay KK , Chieng YL . Osteonecrosis of mandible: a rare complication of long-term steroid use. J Oral Maxillofac Surgery Med Pathol 2014;27.doi:10.1016\/j.ajoms.2014.05.009","DOI":"10.1016\/j.ajoms.2014.05.009"},{"key":"2025082709164643000_14.3.e241298.13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3892\/mco.2016.1100","article-title":"Osteonecrosis of the jaw associated with everolimus: a case report","volume":"6","author":"Yamamoto","year":"2017","journal-title":"Mol Clin Oncol"},{"key":"2025082709164643000_14.3.e241298.14","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90433-5"},{"key":"2025082709164643000_14.3.e241298.15","first-page":"421","article-title":"Avascular necrosis of the femoral head secondary to corticosteroid therapy for graft-versus-host disease after marrow transplantation: effective therapy with hip arthroplasty","volume":"2","author":"Atkinson","year":"1987","journal-title":"Bone Marrow Transplant"},{"key":"2025082709164643000_14.3.e241298.16","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000138026.40907.38"},{"key":"2025082709164643000_14.3.e241298.17","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"2025082709164643000_14.3.e241298.18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00003086-198903000-00035","article-title":"Osteogenic stem cells and the stromal system of bone and marrow","author":"Beresford","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"2025082709164643000_14.3.e241298.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(99)00076-4"},{"key":"2025082709164643000_14.3.e241298.20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020800"},{"key":"2025082709164643000_14.3.e241298.21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031206"},{"key":"2025082709164643000_14.3.e241298.22","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24474"},{"key":"2025082709164643000_14.3.e241298.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.10.027"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-241298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:16:53Z","timestamp":1756311413000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-241298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,4]]},"published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1136\/bcr-2020-241298"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-241298","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}