{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:44:26Z","timestamp":1784684666934,"version":"3.55.0"},"reference-count":6,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,16]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>A 63-year-old woman presented with jaundice and epigastric pain for 2 weeks. Physical examination revealed marked jaundice, and palpable gallbladder with right upper quadrant tenderness. Liver function test was remarkable for hepatocellular injury pattern. Antinuclear antibody and anti-smooth muscle antibody were positive with high titre and serum IgG was elevated more than upper normal range. Ultrasound and CT scan demonstrated mildly diffuse periportal oedema of liver parenchyma and markedly diffuse gallbladder wall thickening up to 2 cm. Liver histology showed focal interface hepatitis with prominent plasma cell infiltration and cluster formation, moderate lobular spotty necrosis and emperipolesis consistent with autoimmune hepatitis. The patient was treated with steroid and azathioprine. She had complete resolution of symptoms and normal biochemical laboratory results. Diffuse gallbladder thickening was seen in acute hepatitis from definite autoimmune hepatitis.<\/jats:p>","DOI":"10.1136\/bcr-2020-241325","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T12:12:14Z","timestamp":1622463134000},"page":"e241325","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Diffuse gallbladder wall thickening in autoimmune hepatitis: an unusual presentation"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-781X","authenticated-orcid":false,"given":"Chitchai","family":"Rattananukrom","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand"},{"name":"Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napat","family":"Angkathunyakul","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhasnee","family":"Sobhonslidsuk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"2025082710021545000_14.5.e241325.1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1712"},{"key":"2025082710021545000_14.5.e241325.2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2214\/ajr.136.2.337","article-title":"Sonography of the thickened gallbladder wall: a nonspecific finding","volume":"136","author":"Shlaer","year":"1981","journal-title":"AJR Am J Roentgenol"},{"key":"2025082710021545000_14.5.e241325.3","doi-asserted-by":"crossref","first-page":"W1","DOI":"10.2214\/AJR.12.10386","article-title":"Gallbladder wall thickening","volume":"202","author":"Runner","year":"2014","journal-title":"AJR Am J Roentgenol"},{"key":"2025082710021545000_14.5.e241325.4","doi-asserted-by":"crossref","DOI":"10.1016\/S0016-5107(00)14837-0","article-title":"Gallbladder thickening in patients with acute hepatitis: what is the cause?","volume":"51","author":"Baik","year":"2000","journal-title":"Gastrointest Endosc"},{"key":"2025082710021545000_14.5.e241325.5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF01296260","article-title":"Gallbladder abnormalities in acute infectious hepatitis. A prospective study","volume":"29","author":"Maudgal","year":"1984","journal-title":"Dig Dis Sci"},{"key":"2025082710021545000_14.5.e241325.6","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20542"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-241325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:02:26Z","timestamp":1756314146000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-241325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":6,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,31]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/bcr-2020-241325"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-241325","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}