{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:39:04Z","timestamp":1757450344660,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,1]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Dorsal root ganglion stimulation (DRGS) therapy is a rapidly emerging tool being used by pain physicians in the treatment of chronic pain. Complex regional pain syndrome (CRPS), a debilitating disease whose mechanism is still has yet to be fully elucidated, is a common pathology targeted by DRGS therapy, often better results than traditional spinal cord stimulation. DRGS therapy, however, is not bereft of complications. Lead migration and fracture are two examples in particular that are among the most common of these complications. The authors report an unusual case of lost efficacy due to lead fractures in patients with CRPS treated with DRGS. The case report narrates identification, management and probable mechanism of DRGS lead fracture. The structural instability of DRGS leads can yield distressing symptoms at any point during the therapy, and physicians should be cognisant of the complications of DRGS therapy.<\/jats:p>","DOI":"10.1136\/bcr-2020-241353","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T11:17:46Z","timestamp":1621509466000},"page":"e241353","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Dorsal root ganglion stimulation lead fractures: potential mechanisms and ways to avoid"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-1808","authenticated-orcid":false,"given":"Gaurav","family":"Chauhan","sequence":"first","affiliation":[{"name":"Anesthesiology, Chronic Pain Divison, UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon I","family":"Roth","sequence":"additional","affiliation":[{"name":"Pain Management, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagy","family":"Mekhail","sequence":"additional","affiliation":[{"name":"Pain Management, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"2025082802161319000_14.5.e241353.1","doi-asserted-by":"crossref","first-page":"h2730","DOI":"10.1136\/bmj.h2730","article-title":"Complex regional pain syndrome","volume":"29","author":"Bruehl","year":"2015","journal-title":"BMJ"},{"key":"2025082802161319000_14.5.e241353.2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pjnns.2014.05.007","article-title":"Complex regional pain syndrome of the upper limb: a review","volume":"48","author":"\u017byluk","year":"2014","journal-title":"Neurol Neurochir Pol"},{"key":"2025082802161319000_14.5.e241353.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00065-4"},{"key":"2025082802161319000_14.5.e241353.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.008"},{"key":"2025082802161319000_14.5.e241353.5","article-title":"Interventions for treating pain and disability in adults with complex regional pain syndrome","volume":"30","author":"O'Connell","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2025082802161319000_14.5.e241353.6","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12247"},{"key":"2025082802161319000_14.5.e241353.7","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/ner.12651","article-title":"Relevant anatomy, morphology, and implantation techniques of the dorsal root ganglia at the lumbar levels","volume":"20","author":"Vancamp","year":"2017","journal-title":"Neuromodulation"},{"key":"2025082802161319000_14.5.e241353.8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/ner.12754","article-title":"Mechanisms of dorsal root ganglion stimulation in pain suppression: a computational modeling analysis","volume":"21","author":"Kent","year":"2018","journal-title":"Neuromodulation"},{"key":"2025082802161319000_14.5.e241353.9","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1093\/pm\/pnz012","article-title":"Unique characteristics of the dorsal root ganglion as a target for neuromodulation","volume":"20","author":"Esposito","year":"2019","journal-title":"Pain Med"},{"key":"2025082802161319000_14.5.e241353.10","doi-asserted-by":"crossref","unstructured":"Mekhail N , Deer TR , Poree L . 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