{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:10:13Z","timestamp":1756375813362,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,8,3]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Autoimmune hepatitis is a diagnosis rarely made in pregnancy, especially in the setting of acute liver failure. If unrecognised and untreated, it can result in significant fetal and maternal morbidity and mortality. We report a case of acute liver failure in a patient presenting at 17 weeks\u2019 gestation. She was diagnosed with autoimmune hepatitis via transjugular liver biopsy. Prednisone therapy was initiated, resulting in disease remission for the remainder of her pregnancy. Induction of labour at 37 weeks\u2019 gestation resulted in delivery of a healthy small for gestational age neonate. Prompt diagnosis of a non-obstetrical aetiology for acute liver failure in pregnancy is critical to provide the appropriate therapy to achieve an optimal pregnancy outcome.<\/jats:p>","DOI":"10.1136\/bcr-2020-241355","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T13:00:16Z","timestamp":1628686816000},"page":"e241355","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Acute liver failure in pregnancy due to autoimmune hepatitis"],"prefix":"10.1136","volume":"14","author":[{"given":"Sonia","family":"Sajja","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, William Beaumont Hospital - Royal Oak, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Idler","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine, William Beaumont Hospital - Royal Oak, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaber","family":"Saad","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, William Beaumont Hospital - Royal Oak, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray","family":"Bahado-Singh","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine, William Beaumont Hospital - Royal Oak, Royal Oak, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"2025082802403822000_14.8.e241355.1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ccc.2015.08.005","article-title":"Liver failure in pregnancy","volume":"32","author":"Bacak","year":"2016","journal-title":"Crit Care Clin"},{"key":"2025082802403822000_14.8.e241355.2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23584"},{"key":"2025082802403822000_14.8.e241355.3","first-page":"504","article-title":"Management of autoimmune hepatitis in pregnant women","volume":"13","author":"Peters","year":"2017","journal-title":"Gastroenterol Hepatol"},{"key":"2025082802403822000_14.8.e241355.4","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318176b8c5"},{"key":"2025082802403822000_14.8.e241355.5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cld.434","article-title":"Liver Biopsy-Transjugular","volume":"4","author":"Schwarzer","year":"2014","journal-title":"Clin Liver Dis"},{"key":"2025082802403822000_14.8.e241355.6","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1016\/j.cgh.2018.12.030","article-title":"Presentation and outcomes of pregnancy in patients with autoimmune hepatitis","volume":"17","author":"Llovet","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025082802403822000_14.8.e241355.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00479.x"},{"key":"2025082802403822000_14.8.e241355.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.12.002"},{"key":"2025082802403822000_14.8.e241355.9","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/apt.14925","article-title":"Pregnancy and birth outcomes in a Danish nationwide cohort of women with autoimmune hepatitis and matched population controls","volume":"48","author":"Gr\u00f8nbaek","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"2025082802403822000_14.8.e241355.10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/liv.12901","article-title":"Increased risk of preterm birth in women with autoimmune hepatitis - a nationwide cohort study","volume":"36","author":"Stokkeland","year":"2016","journal-title":"Liver Int"},{"key":"2025082802403822000_14.8.e241355.11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.semarthrit.2005.03.002","article-title":"Autoimmune hepatitis and pregnancy: a rheumatologist's dilemma","volume":"35","author":"Candia","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"2025082802403822000_14.8.e241355.12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/00365521.2015.1115893","article-title":"Pregnancy and childbirth in women with autoimmune hepatitis is safe, even in compensated cirrhosis","volume":"51","author":"Danielsson Borss\u00e9n","year":"2016","journal-title":"Scand J Gastroenterol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-241355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:40:46Z","timestamp":1756374046000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-241355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":12,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,11]]},"published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1136\/bcr-2020-241355"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-241355","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}