{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:35:55Z","timestamp":1787016955421,"version":"build-2736575974"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,6]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>This is a rare presentation of scrub typhus with cerebral venous thrombosis. A 32-year-old woman presented with signs of raised intracranial tension. Examination revealed maculopapular skin rashes and an \u2018eschar\u2019 over the right thigh. Nuchal rigidity and bilateral papilloedema were found. Scrub typhus was diagnosed by the presence of IgM antibody in serum. CT scan of the brain showed cerebral oedema. MRI of the brain was normal. Magnetic resonance venography of the brain showed thrombosis of several venous sinuses. Cerebrospinal fluid analysis revealed lymphocytic pleocytosis with raised protein level. Other causes of prothrombotic states were ruled out by doing specific test results. There was no history of hormonal contraception and prolonged bed rest. A case of scrub typhus complicated with meningoencephalitis and cerebral venous thrombosis was diagnosed. She responded to treatment with doxycycline, anticoagulants, antipyrectics and intravenous saline. Early identification of such atypical neurological involvement in scrub typhus was helpful in satisfactory outcome.<\/jats:p>","DOI":"10.1136\/bcr-2020-241401","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T13:42:58Z","timestamp":1619617378000},"page":"e241401","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Scrub typhus with cerebral venous sinus thrombosis: a rare presentation"],"prefix":"10.1136","volume":"14","author":[{"given":"Sayonee","family":"Das","sequence":"first","affiliation":[{"name":"Internal Medicine, KPC Medical College and Hospital, Jadavpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidhartha","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Neuro-Medicine, KPC Medical College and Hospital, Jadavpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kausik","family":"Munsi","sequence":"additional","affiliation":[{"name":"Internal Medicine, KPC Medical College and Hospital, Jadavpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Basu","sequence":"additional","affiliation":[{"name":"Neuro-Medicine, KPC Medical College and Hospital, Jadavpur, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"2025082700565575000_14.4.e241401.1","first-page":"93","volume-title":"Biology of rickettsial diseases","volume":"Vol1","author":"Brown","year":"1988"},{"key":"2025082700565575000_14.4.e241401.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07391.x"},{"key":"2025082700565575000_14.4.e241401.3","doi-asserted-by":"publisher","DOI":"10.1258\/004947506778604715"},{"key":"2025082700565575000_14.4.e241401.4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308722"},{"key":"2025082700565575000_14.4.e241401.5","doi-asserted-by":"publisher","DOI":"10.1177\/0049475516636543"},{"key":"2025082700565575000_14.4.e241401.6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/0972-2327.107701","article-title":"Neurological manifestations of scrub typhus","volume":"16","author":"Sameer","year":"2013","journal-title":"Ann of Indian Academy of Neurology"},{"key":"2025082700565575000_14.4.e241401.7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4103\/jnrp.jnrp_44_17","article-title":"Neuropsychiatric manifestations of scrub typhus","volume":"8","author":"Mahajan","year":"2017","journal-title":"J Neurosci Rural Pract"},{"key":"2025082700565575000_14.4.e241401.8","doi-asserted-by":"crossref","unstructured":"Sekeyov\u00e1 Z , Danchenko M , Filip\u010d\u00edk P , Peter Filipi P , et al . Rickettsial infections of the central nervous system. PLoS Negl Trop Dis;13:e0007469 http:\/\/doi.org\/10.1371\/journal pntd 0007469, Aug.2019 doi:10.1371\/journal.pntd.0007469","DOI":"10.1371\/journal.pntd.0007469"},{"key":"2025082700565575000_14.4.e241401.9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4103\/0028-3886.136991","article-title":"Cerebral venous sinus thrombosis presentation in severe scrub typhus infection: a rare entity","volume":"62","author":"Jena","year":"2014","journal-title":"Neurol India"},{"key":"2025082700565575000_14.4.e241401.10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.32677\/IJCR.2019.v05.i01.008","article-title":"Cerebral venous sinus thrombosis in scrub typhus infection: a rare presentation","volume":"5","author":"Sardana","year":"2019","journal-title":"Indian J of case reports"},{"key":"2025082700565575000_14.4.e241401.11","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.76.895.269"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-241401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:57:05Z","timestamp":1756281425000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-241401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,28]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/bcr-2020-241401"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-241401","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}