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Yet, with affected patients often surviving into reproductive age, appropriate management of the peripartum phase is essential to ensure positive maternal and fetal outcomes.<\/jats:p>\n               <jats:p>Reassuringly, the vast majority of offspring of parturients with HHH syndrome have normal developmental outcomes; yet as seen here, fetal growth restriction does appear more frequently. Furthermore, in addition to the absent fetal corpus callosum observed in this case, other fetal cerebral abnormalities, including speech delay and intellectual impairment, have been recognised.<\/jats:p>\n               <jats:p>Unregulated dietary intake is one proposed factor for the observed disruption in fetal growth and early cerebral development. These stipulations not only reinforce the importance of extensive planning and teamwork, but also demonstrate the importance of timely intervention by a metabolic dietician and dietary compliance in the early organogenesis stage of pregnancy.<\/jats:p>","DOI":"10.1136\/bcr-2020-241424","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T12:14:04Z","timestamp":1625141644000},"page":"e241424","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Role of early management of hyperornithinaemia\u2010hyperammonaemia\u2010homocitrullinuria syndrome in pregnancy"],"prefix":"10.1136","volume":"14","author":[{"given":"Matthew James","family":"Billingham","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Birmingham Heartlands Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania","family":"Rizk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Birmingham Heartlands Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"2025082623474409000_14.7.e241424.1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0242-9"},{"key":"2025082623474409000_14.7.e241424.2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1969.02100030085009"},{"key":"2025082623474409000_14.7.e241424.3","doi-asserted-by":"publisher","DOI":"10.1038\/9658"},{"key":"2025082623474409000_14.7.e241424.4","doi-asserted-by":"crossref","unstructured":"Ah Mew N , Pappa MB , Gropman AL . 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