{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:14:14Z","timestamp":1783336454511,"version":"3.54.6"},"reference-count":27,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,6,11]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Cortical spreading depression (CSD) has been directly observed in humans with malignant stroke, traumatic brain injury and subarachnoid haemorrhage and is also considered to be the correlate of migraine aura. We report on a 76-year-old woman with new-onset episodes of headache, paraesthesia, hemiparesis and dysarthria, in whom a small cortical subarachnoid haemorrhage was diagnosed with MRI. Repeated diffusion-weighted MRI scans shortly after transient focal neurological episodes as well as diagnostic workup were normal, which makes recurrent transient ischaemic attacks unlikely. Ictal electroencephalogram recordings showed no epileptic activity. Long-term follow-up revealed a diagnosis of probable cerebral amyloid angiopathy. We propose that CSD could be a pathophysiological correlate of transient focal neurological deficits in patients with cortical bleeding.<\/jats:p>","DOI":"10.1136\/bcr-2020-241479","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T11:50:48Z","timestamp":1625485848000},"page":"e241479","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Recurrent migraine aura-like symptoms in an elderly woman: symptomatic cortical spreading depression?"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-1992","authenticated-orcid":false,"given":"Kerstin","family":"Gl\u00f6ssmann","sequence":"first","affiliation":[{"name":"Department of Neurology, Clinic Hietzing, Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinic Hietzing, Wien, Austria"},{"name":"Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, Vienna, Austria"},{"name":"Sigmund Freud Private University, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Peter","family":"Koren","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinic Hietzing, Wien, Austria"},{"name":"Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-9754","authenticated-orcid":false,"given":"Franz","family":"Riederer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinic Hietzing, Wien, Austria"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"2025082703492418000_14.7.e241479.1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1944.7.6.359"},{"key":"2025082703492418000_14.7.e241479.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01983.x"},{"key":"2025082703492418000_14.7.e241479.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63020781.x"},{"key":"2025082703492418000_14.7.e241479.4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws010"},{"key":"2025082703492418000_14.7.e241479.5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad605"},{"key":"2025082703492418000_14.7.e241479.6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/head.12197","article-title":"Headache as a crucial symptom in the etiology of convexal subarachnoid hemorrhage","volume":"54","author":"Rico","year":"2014","journal-title":"Headache"},{"key":"2025082703492418000_14.7.e241479.7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d55efa"},{"key":"2025082703492418000_14.7.e241479.8","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004298"},{"key":"2025082703492418000_14.7.e241479.9","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.621847"},{"key":"2025082703492418000_14.7.e241479.10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/ene.12926","article-title":"Distinguishing clinical and radiological features of non-traumatic convexal subarachnoid hemorrhage","volume":"23","author":"Graff-Radford","year":"2016","journal-title":"Eur J Neurol"},{"key":"2025082703492418000_14.7.e241479.11","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1986"},{"key":"2025082703492418000_14.7.e241479.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.03.021"},{"key":"2025082703492418000_14.7.e241479.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.01.011"},{"key":"2025082703492418000_14.7.e241479.14","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200305000-00002"},{"key":"2025082703492418000_14.7.e241479.15","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1177\/0271678X16654496","article-title":"Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID Research Group","volume":"37","author":"Dreier","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"2025082703492418000_14.7.e241479.16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071582498"},{"key":"2025082703492418000_14.7.e241479.17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s00482-008-0653-9","article-title":"[Cortical spreading depression (CSD): a neurophysiological correlate of migraine aura]","volume":"22","author":"Richter","year":"2008","journal-title":"Schmerz"},{"key":"2025082703492418000_14.7.e241479.18","first-page":"318","article-title":"Cerebral blood flow in migraine with aura","volume":"40","author":"Olesen","year":"1992","journal-title":"Pathol Biol"},{"key":"2025082703492418000_14.7.e241479.19","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21871"},{"key":"2025082703492418000_14.7.e241479.20","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410384885"},{"key":"2025082703492418000_14.7.e241479.21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01570.x"},{"key":"2025082703492418000_14.7.e241479.22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11357-019-00142-7","article-title":"Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury","volume":"42","author":"Major","year":"2020","journal-title":"Geroscience"},{"key":"2025082703492418000_14.7.e241479.23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jocn.2015.08.004","article-title":"Cortical spreading depolarization: pathophysiology, implications, and future directions","volume":"24","author":"Kramer","year":"2016","journal-title":"J Clin Neurosci"},{"key":"2025082703492418000_14.7.e241479.24","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.191"},{"key":"2025082703492418000_14.7.e241479.25","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.063750"},{"key":"2025082703492418000_14.7.e241479.26","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20778"},{"key":"2025082703492418000_14.7.e241479.27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.seizure.2009.01.002","article-title":"Brivaracetam inhibits spreading depression in rat neocortical slices in vitro","volume":"18","author":"Margineanu","year":"2009","journal-title":"Seizure"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-241479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:49:32Z","timestamp":1756291772000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-241479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":27,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,5]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1136\/bcr-2020-241479"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-241479","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}