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These patients can be asymptomatic or develop complications like skin bruising, epistaxis and even intracranial haemorrhage. We present a case of a 64-year-old man who developed eptifibatide-induced profound thrombocytopaenia leading to extensive skin bruising. He was treated with platelet transfusions followed by prompt improvement in platelet count.<\/jats:p>","DOI":"10.1136\/bcr-2021-241594","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T12:40:14Z","timestamp":1623674414000},"page":"e241594","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Eptifibatide-induced profound thrombocytopaenia: a rare complication"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7779-7810","authenticated-orcid":false,"given":"Pranav","family":"Mahajan","sequence":"first","affiliation":[{"name":"Internal Medicine, Carle Foundation Hospital, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Ayub","sequence":"additional","affiliation":[{"name":"Internal Medicine, Carle Foundation Hospital, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Azimi","sequence":"additional","affiliation":[{"name":"Carle Illiinois College of Medicine, University of Illinois, Champaign, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Adoni","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Cardiology, Carle Foundation Hospital, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"2025082708115777000_14.6.e241594.1","first-page":"86","article-title":"Eptifibatide-induced thrombocytopenia: with thrombosis and disseminated intravascular coagulation immediately after left main coronary artery percutaneous coronary angioplasty","volume":"39","author":"Tempelhof","year":"2012","journal-title":"Tex Heart Inst J"},{"key":"2025082708115777000_14.6.e241594.2","doi-asserted-by":"crossref","DOI":"10.1186\/1756-0500-7-107","article-title":"Eptifibatide-induced acute profound thrombocytopenia: a case report","volume":"7","author":"Graidis","year":"2014","journal-title":"BMC Res Notes"},{"key":"2025082708115777000_14.6.e241594.3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9072212","article-title":"Pathophysiology and diagnosis of drug-induced immune thrombocytopenia","volume":"9","author":"Vayne","year":"2020","journal-title":"J Clin Med"},{"doi-asserted-by":"crossref","unstructured":"George JN , Aster RH . 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