{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T02:45:43Z","timestamp":1794365143376,"version":"4.9.0"},"reference-count":18,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,3,25]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Hypoglycaemia due to insulin-like growth factor (IGF)-2 secretion is a paraneoplastic complication of malignancy with significant morbidity that can often go unrecognised due to its uncommon presentation. We report on a case of a 51-year-old man with metastatic haemangiopericytoma presenting with refractory hypoglycaemia, requiring continuous dextrose 10% infusion while in hospital. IGF-2 levels were significantly elevated, in keeping with a rare entity associated with solitary fibrous tumours, known as Doege-Potter syndrome. The patient was managed using uncooked cornstarch in conjunction with debulking of the hepatic tumour burden with bland IR-guided transarterial embolisation, and eventual surgical resection to treat his non-islet cell tumour hypoglycaemia (NICTH). The case highlights this rare paraneoplastic phenomenon that should be included in the differential for hypoglycaemia, especially if a history of a solitary fibrous tumour is elicited. Our case is the first to document a successful approach to treating the hypoglycaemia using preoperative transarterial bland embolisation.<\/jats:p>","DOI":"10.1136\/bcr-2021-241724","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T13:30:12Z","timestamp":1618493412000},"page":"e241724","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Successful multidisciplinary treatment of Doege-Potter syndrome: hypoglycaemia caused by paraneoplastic IGF-2 production by a metastatic haemangiopericytoma"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4176-4827","authenticated-orcid":false,"given":"Jeffery","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Athayde","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of British Columbia Faculty of Medicine, New Westminster, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of British Columbia Faculty of Medicine, New Westminster, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"2025082622550113000_14.4.e241724.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(76)80006-8"},{"key":"2025082622550113000_14.4.e241724.2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198910000-00003"},{"key":"2025082622550113000_14.4.e241724.3","doi-asserted-by":"crossref","DOI":"10.3350\/cmh.2016.22.1.188","article-title":"Liver metastasis of meningeal hemangiopericytoma: a study of 5 cases","volume":"22","author":"Lo","year":"2016","journal-title":"Clin Mol Hepatol"},{"key":"2025082622550113000_14.4.e241724.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00833.x"},{"key":"2025082622550113000_14.4.e241724.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00297.x"},{"key":"2025082622550113000_14.4.e241724.6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1440-1746.1998.tb00544.x","article-title":"Case report: insulin-like growth factor II expression in hepatocellular carcinoma with alcoholic liver fibrosis accompanied by hypoglycaemia","volume":"13","author":"Yamaguchi","year":"1998","journal-title":"J Gastroenterol Hepatol"},{"key":"2025082622550113000_14.4.e241724.7","doi-asserted-by":"crossref","unstructured":"Han G , Zhang Z , Shen X . 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