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An increase in the frequency of SMART syndrome can be attributed to an increase in the survival rate of patients undergoing radiation therapy This study details the case of a 60-year-old woman with a history of small-cell lung carcinoma, who, in her late forties, was treated with prophylactic cranial irradiation. She presented at the emergency room with acute onset of global aphasia, lethargy and headache that started a few days before.<\/jats:p>","DOI":"10.1136\/bcr-2021-241748","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T13:37:05Z","timestamp":1618493825000},"page":"e241748","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["SMART syndrome: a late-onset and not always reversible complication of radiotherapy"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-8925","authenticated-orcid":false,"given":"Raquel","family":"Rocha","sequence":"first","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Neurology Department, Hospital Pedro Hispano, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Pedro Hispano, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe","family":"Correia","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Pedro Hispano, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"2025082708462469000_14.4.e241748.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01184.x"},{"key":"2025082708462469000_14.4.e241748.2","doi-asserted-by":"crossref","unstructured":"Black DF , Morris JM , Lindell EP , et al . 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Smart syndrome: classic transient symptoms leading to an unusual unfavorable outcome. Rev Neurol (Paris) [Internet] 2016:1\u20137 http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0035378716300765%5Cnhttp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27919464"},{"key":"2025082708462469000_14.4.e241748.8","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2396-6"},{"key":"2025082708462469000_14.4.e241748.9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/NRL.0000000000000003","article-title":"The syndrome of stroke-like migraine attacks after radiation therapy associated with prolonged unresponsiveness in an adult patient","volume":"19","author":"Tomek","year":"2015","journal-title":"Neurologist"},{"key":"2025082708462469000_14.4.e241748.10","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13870"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-241748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:46:35Z","timestamp":1756309595000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-241748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,15]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/bcr-2021-241748"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-241748","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}