{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:06:56Z","timestamp":1756339616054,"version":"3.44.0"},"reference-count":30,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,25]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>The Chiari I malformation (CM-I) is characterised by overcrowding of the posterior fossa and descent of the cerebellar tonsils and is associated with syringomyelia. With the increasing availability of magnetic resonance imaging, CM-I is placing a growing burden on neurosurgical services. However, its natural history remains poorly understood, and the timing and nature of surgical intervention is controversial. We present a case of a significant, symptomatic CM-I with associated syrinx which underwent complete spontaneous resolution over a 4-year period. Spontaneous regression of Chiari malformation and syringomyelia is exceedingly rare; a literature review reveals 15 other cases and only one case which underwent complete resolution. The present case and literature review suggest a more benign natural history of CM-I and support a more conservative approach to its management. Further studies are required to determine whether any factors can predict resolution for certain patient cohorts.<\/jats:p>","DOI":"10.1136\/bcr-2021-241789","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T12:11:24Z","timestamp":1624277484000},"page":"e241789","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Spontaneous resolution of a Chiari malformation with syringomyelia"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-1383","authenticated-orcid":false,"given":"Hadleigh","family":"Cuthbert","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Hospital of North Staffordshire NHS Trust, Stoke-on-Trent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-5291","authenticated-orcid":false,"given":"Joshua","family":"Pepper","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of North Staffordshire NHS Trust, Stoke-on-Trent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupert","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of North Staffordshire NHS Trust, Stoke-on-Trent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082712050848000_14.6.e241789.1","DOI":"10.1055\/s-0029-1206803"},{"doi-asserted-by":"publisher","key":"2025082712050848000_14.6.e241789.2","DOI":"10.1097\/00004728-198511000-00005"},{"doi-asserted-by":"publisher","key":"2025082712050848000_14.6.e241789.3","DOI":"10.1055\/s-0033-1357362"},{"doi-asserted-by":"publisher","key":"2025082712050848000_14.6.e241789.4","DOI":"10.1227\/NEU.0b013e31825c3426"},{"key":"2025082712050848000_14.6.e241789.5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.wneu.2015.11.087","article-title":"A systematic review of Chiari I malformation: techniques and outcomes","volume":"88","author":"Zhao","year":"2016","journal-title":"World Neurosurg"},{"key":"2025082712050848000_14.6.e241789.6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3171\/jns.1991.74.2.0283","article-title":"Spontaneous decompression of syringomyelia: magnetic resonance imaging findings. 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