{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:10:04Z","timestamp":1756321804698,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,18]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>We present a case of mesenteric ischaemia caused by hypermagnesaemia after ingestion of a large oral dose of magnesium citrate, which resulted in smooth muscle relaxation, hypotension and bowel infarction. The patient had a history of chronic bowel dysmotility and renal impairment. On operative exploration, the bowel was noted to have a distinct pattern of ischaemia along its antimesenteric border. Small bowel resection was performed, and the patient was left in discontinuity, with definitive repair and anastomosis performed 24 hours later. The patient\u2019s magnesium level was 8.39 mg\/dL, which was treated with intermittent haemodialysis and eventually normalised over several sessions. Our patient recovered and was discharged after a month-long hospitalisation. She returned shortly after with respiratory failure and died. On review of the literature, we identified similar cases and present a pathophysiological mechanism of hypermagnesaemia causing mesenteric ischaemia, consistent between our cases and those already reported.<\/jats:p>","DOI":"10.1136\/bcr-2021-241928","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T11:55:07Z","timestamp":1624362907000},"page":"e241928","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Hypermagnesaemia causing mesenteric ischaemia and small bowel infarction"],"prefix":"10.1136","volume":"14","author":[{"given":"Grant","family":"Hubbard","sequence":"first","affiliation":[{"name":"Department of Surgery, Western Reserve Hospital, Cuyahoga Falls, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Nerad","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Wojtasik","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospitals Portage Medical Center, Ravenna, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"2025082711283972000_14.6.e241928.1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.amjms.2017.08.013","article-title":"Fatal hypermagnesemia due to laxative use","volume":"355","author":"Bokhari","year":"2018","journal-title":"Am J Med Sci"},{"key":"2025082711283972000_14.6.e241928.2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40792-016-0145-6","article-title":"Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case","volume":"2","author":"Sugiyama","year":"2016","journal-title":"Surg Case Rep"},{"key":"2025082711283972000_14.6.e241928.3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s13730-018-0359-5","article-title":"Severe hypermagnesemia induced by magnesium oxide ingestion: a case series","volume":"8","author":"Yamaguchi","year":"2019","journal-title":"CEN Case Rep"},{"key":"2025082711283972000_14.6.e241928.4","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.44.448"},{"key":"2025082711283972000_14.6.e241928.5","doi-asserted-by":"crossref","DOI":"10.3349\/ymj.2013.54.3.797","article-title":"Hypermagnesemia accompanied with colonic perforation in a hemodialysis patient","volume":"54","author":"Yoon","year":"2013","journal-title":"Yonsei Med J"},{"key":"2025082711283972000_14.6.e241928.6","first-page":"1","article-title":"Severe symptomatic hypermagnesemia associated with over-the-counter laxatives in a patient with renal failure and sigmoid volvulus","volume":"2014","author":"Khairi","year":"2014","journal-title":"Case Rep Nephrol"},{"key":"2025082711283972000_14.6.e241928.7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ams2.334","article-title":"The characteristics of patients with hypermagnesemia who underwent emergency hemodialysis","volume":"5","author":"Nishikawa","year":"2018","journal-title":"Acute Med Surg"},{"key":"2025082711283972000_14.6.e241928.8","first-page":"47","article-title":"Magnesium metabolism and its disorders","volume":"24","author":"Swaminathan","year":"2003","journal-title":"Clin Biochem Rev"},{"key":"2025082711283972000_14.6.e241928.9","unstructured":"Lawrence PF , Bell RM , Dayton MT . Essentials of general surgery. Lippincott Williams & Wilkins, 2012: 586."},{"key":"2025082711283972000_14.6.e241928.10","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1482"},{"key":"2025082711283972000_14.6.e241928.11","unstructured":"Cascella M , Vaqar S . Hypermagnesemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2021."},{"key":"2025082711283972000_14.6.e241928.12","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12411"},{"key":"2025082711283972000_14.6.e241928.13","doi-asserted-by":"crossref","DOI":"10.1186\/s12882-020-1713-3","article-title":"Serum magnesium, mortality and disease progression in chronic kidney disease","volume":"21","author":"Azem","year":"2020","journal-title":"BMC Nephrol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-241928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:28:51Z","timestamp":1756319331000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-241928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6,22]]},"published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1136\/bcr-2021-241928"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-241928","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}