{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:25Z","timestamp":1756339525328,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"6","funder":[{"DOI":"10.13039\/501100005918","name":"Christian Medical College, Vellore","doi-asserted-by":"publisher","award":["925255"],"award-info":[{"award-number":["925255"]}],"id":[{"id":"10.13039\/501100005918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,23]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>A 48-year-old man who is a known case of bipolar disorder was maintaining well on a combination of carbamazepine and quetiapine for 3 years until he developed fever, severe leucopenia and lymphadenopathy, along with significant loss of weight and appetite. A thorough investigation revealed Kikuchi\u2019s disease as a likely histological diagnosis. Carbamazepine was discontinued and quetiapine was titrated for the management of psychiatric symptoms. The patient gradually made good recovery following discontinuation of carbamazepine and the diagnosis of drug-induced myelosuppression was retained. Clinicians need to be aware of the adverse effects of medications being used for long-term prophylaxis and other possible conditions that may change the course of drug effects.<\/jats:p>","DOI":"10.1136\/bcr-2021-241973","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T12:24:30Z","timestamp":1625055870000},"page":"e241973","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Carbamazepine-induced delayed-onset agranulocytosis in a case of bipolar disorder with Kikuchi\u2019s disease"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-9546","authenticated-orcid":false,"given":"Cebasta","family":"Irudayaraj","sequence":"first","affiliation":[{"name":"Psychiatry, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-436X","authenticated-orcid":false,"given":"Raviteja","family":"Innamuri","sequence":"additional","affiliation":[{"name":"Psychiatry, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-9484","authenticated-orcid":false,"given":"Dheeraj","family":"Kattula","sequence":"additional","affiliation":[{"name":"Psychiatry, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"2025082708393263000_14.6.e241973.1","unstructured":"Sedhai YR , Lamichhane A , Gupta V . Agranulocytosis. Treasure Island (FL: StatPearls Publishing, 2020. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559275\/"},{"key":"2025082708393263000_14.6.e241973.2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.3.413"},{"key":"2025082708393263000_14.6.e241973.3","doi-asserted-by":"crossref","unstructured":"DNA typing of HLA class II genes (HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi\u2019s disease) [Internet]. Vol. 54, Tissue antigens. Tissue Antigens, 1999. Available: https:\/\/pubmed.ncbi.nlm.nih.gov\/10519361\/ [Accessed 1 Oct 2020].","DOI":"10.1034\/j.1399-0039.1999.540305.x"},{"key":"2025082708393263000_14.6.e241973.4","first-page":"1","article-title":"Hla association with drug-induced adverse reactions","volume":"2017","author":"Fan","year":"2017","journal-title":"J Immunol Res"},{"key":"2025082708393263000_14.6.e241973.5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.5455\/bcp.20151219072235","article-title":"Neutropenia and thrombocytopenia induced by quetiapine monotherapy: a case report and review of literature","volume":"26","author":"Arslan","year":"2016","journal-title":"Klinik Psikofarmakoloji B\u00fclteni-Bulletin of Clinical Psychopharmacology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-241973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:39:40Z","timestamp":1756309180000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-241973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6,30]]},"published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1136\/bcr-2021-241973"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-241973","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}