{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:52:38Z","timestamp":1761598358701,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,6]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>The COVID-19 pandemic is revealing growing reports of atypical presentation of the disease beyond the respiratory system. SARS-CoV-2 infection has been linked to multisystem vasculopathy including cardiopulmonary, cerebral and renal vasculature, potentially brought on by a dysregulated host immune response in a probable setting of a cytokine storm. Here, we describe a case of a previously healthy and active 74-year-old man presenting with acute cognitive decline with preceding non-specific influenza-like symptoms. He was then diagnosed with cerebral amyloid angiopathy (CAA)-associated intracerebral haemorrhage and was found to be COVID-19 positive. COVID-19-induced immune response may have further compromised the cerebral vessels already weakened by CAA, triggering multiple microhaemorrhages leading to clinical presentation. The limited evidence about the heterogeneity of COVID-19 manifestations suggests that clinicians should be aware and screen for concurrent COVID-19 in patients presenting with neurological features during the peak of this pandemic, as this offers the best chance for better clinical outcome.<\/jats:p>","DOI":"10.1136\/bcr-2021-242028","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T11:27:41Z","timestamp":1627385261000},"page":"e242028","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["COVID-19-related vasculopathy of the brain"],"prefix":"10.1136","volume":"14","author":[{"given":"Hui Wen","family":"Liang","sequence":"first","affiliation":[{"name":"Diabetes and Endocrinology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai Man","family":"Mung","sequence":"additional","affiliation":[{"name":"University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Douglass","sequence":"additional","affiliation":[{"name":"Neurology, Manchester Centre for Clinical Neurosciences, Salford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward B","family":"Jude","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"2025082711565322000_14.7.e242028.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"2025082711565322000_14.7.e242028.2","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2020-000431"},{"key":"2025082711565322000_14.7.e242028.3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/1747493020937189","article-title":"Cerebral ischemic and hemorrhagic complications of coronavirus disease 2019","volume":"15","author":"Sweid","year":"2020","journal-title":"Int J Stroke"},{"key":"2025082711565322000_14.7.e242028.4","doi-asserted-by":"crossref","first-page":"100250","DOI":"10.1016\/j.ensci.2020.100250","article-title":"Large vessel stroke and COVID-19: case report and literature review","volume":"20","author":"Mahboob","year":"2020","journal-title":"eNeurologicalSci"},{"key":"2025082711565322000_14.7.e242028.5","doi-asserted-by":"crossref","unstructured":"Bin MIZ , Balson L , Madathil S . Massive bilateral stroke in a COVID-19 patient. BMJ Case Rep 2020.doi:10.1136\/bcr-2020-236254","DOI":"10.1136\/bcr-2020-236254"},{"key":"2025082711565322000_14.7.e242028.6","doi-asserted-by":"crossref","unstructured":"Hughes C , Nichols T , Pike M . Cerebral venous sinus thrombosis as a presentation of COVID-19. Eur J case reports Intern Med 2020.doi:https:\/\/doi.org\/10.12890\/2020_001691","DOI":"10.12890\/2020_001691"},{"key":"2025082711565322000_14.7.e242028.7","doi-asserted-by":"crossref","unstructured":"Morassi M , Bagatto D , Cobelli M . Stroke in patients with SARS-CoV-2 infection: case series. 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