{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T06:00:17Z","timestamp":1782626417533,"version":"3.54.5"},"reference-count":10,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,15]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1\u2009week. Her visual acuity was no perception of light in the right eye and hand movement in the left eye. There was a generalised restriction of extraocular muscle movements in both eyes. Funduscopy showed a bilateral pale optic disc. A paraneoplastic antigen autoimmune profile showed a positive anti-CV2\/CRMP-5 antibody. CT of the thorax revealed the presence of right apical lung mass, confirmed to be adenocarcinoma through a biopsy. She was scheduled for lung lobectomy and chemotherapy. Unfortunately, her health deteriorated and she passed away eventually.<\/jats:p>","DOI":"10.1136\/bcr-2021-242082","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T13:15:20Z","timestamp":1620825320000},"page":"e242082","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Paraneoplastic optic neuropathy secondary to adenocarcinoma of the lung"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-7632","authenticated-orcid":false,"given":"Jin Yi","family":"Yap","sequence":"first","affiliation":[{"name":"Ophthalmology, University of Science Malaysia School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia"},{"name":"Surgical Department, University of Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Hazabbah","family":"Wan HItam","sequence":"additional","affiliation":[{"name":"University of Science Malaysia\u2014Health Campus, Kubang Kerian, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanihah","family":"Abdul Halim","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Science Malaysia\u2014Kesihatan Campus, Kubang Kerian, Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul Ain","family":"Masnon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Science Malaysia\u2014Kesihatan Campus, Kubang Kerian, Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"2025082713012858000_14.5.e242082.1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3390\/biomedicines8110490","article-title":"Ocular paraneoplastic syndromes","volume":"8","author":"Prze\u017adziecka-Do\u0142yk","year":"2020","journal-title":"Biomedicines"},{"key":"2025082713012858000_14.5.e242082.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.09.001"},{"key":"2025082713012858000_14.5.e242082.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(09)70214-1"},{"key":"2025082713012858000_14.5.e242082.4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ophtha.2019.09.012","article-title":"Collapsin Response-Mediator protein 5-Associated retinitis, vitritis, and optic disc edema","volume":"127","author":"Cohen","year":"2020","journal-title":"Ophthalmology"},{"key":"2025082713012858000_14.5.e242082.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312046"},{"key":"2025082713012858000_14.5.e242082.6","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2169\/internalmedicine.9736-17","article-title":"CV2\/CRMP5-antibody-related paraneoplastic optic neuropathy associated with small-cell lung cancer","volume":"57","author":"Nakajima","year":"2018","journal-title":"Intern Med"},{"key":"2025082713012858000_14.5.e242082.7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10587"},{"key":"2025082713012858000_14.5.e242082.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70060-7"},{"key":"2025082713012858000_14.5.e242082.9","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:19:1:51"},{"key":"2025082713012858000_14.5.e242082.10","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00135-7"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-242082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:01:35Z","timestamp":1756324895000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-242082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,12]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/bcr-2021-242082"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-242082","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}