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Endometrial cancer is rare in women with LNG-IUS as only seven cases have been published in the literature. Although scientific evidence shows LNG-IUS has a protective effect on the endometrium from developing cancer, our report highlights the importance of clinicians to be vigilant in cases of women with LNG-IUS who develop intermittent vaginal bleeding.<\/jats:p>","DOI":"10.1136\/bcr-2021-242094","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T17:10:41Z","timestamp":1620925841000},"page":"e242094","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Development of endometrial cancer after long-term usage of the levonorgestrel-releasing intrauterine system"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0734-6234","authenticated-orcid":false,"given":"Alexander","family":"Steshenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"2021051310100753000_14.5.e242094.1"},{"key":"2021051310100753000_14.5.e242094.2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.8645"},{"key":"2021051310100753000_14.5.e242094.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.02.011"},{"key":"2021051310100753000_14.5.e242094.4","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn397"},{"key":"2021051310100753000_14.5.e242094.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61766-3"},{"key":"2021051310100753000_14.5.e242094.6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/annonc\/mdv484","article-title":"ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up. 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