{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:33:29Z","timestamp":1756384409497,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,29]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>A 52-year-old woman with cystic fibrosis presented to the emergency department with expressive aphasia and right-sided hemiparesis. CT scan of the brain revealed a left middle cerebral artery territory infarct. A diagnosis of cerebral paradoxical embolisation associated with patent foramen ovale and a history of deep venous thrombosis was made. The patient underwent endovascular thrombectomy and percutaneous closure of patent foramen ovale. Current literature, including five published case reports, pertaining to the subject is discussed. The unique aspects of the case are highlighted, including the particular risk of cerebral paradoxical embolisation in patients with cystic fibrosis. The result of this case report, in context to previously reported literature, suggests that clinicians should be aware of paradoxical embolisation in patients with cystic fibrosis via an intracardiac shunt, particularly with implanted vascular access devices and a history of deep venous thrombosis.<\/jats:p>","DOI":"10.1136\/bcr-2021-242302","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:56:33Z","timestamp":1621857393000},"page":"e242302","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral paradoxical embolisation in a patient with cystic fibrosis with patent foramen ovale: a comparative review of literature"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-7689","authenticated-orcid":false,"given":"Taha","family":"Ahmed","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samra Haroon","family":"Lodhi","sequence":"additional","affiliation":[{"name":"Internal Medicine, King Edward Medical University, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael I","family":"Anstead","sequence":"additional","affiliation":[{"name":"Adult and Pediatric Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian W","family":"Messerli","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Gill Heart and Vascular Institute, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"2025082703052828000_14.5.e242302.1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007146"},{"key":"2025082703052828000_14.5.e242302.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2019-000456"},{"key":"2025082703052828000_14.5.e242302.3","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1136\/thx.54.12.1139","article-title":"Paradoxical embolism in a boy with cystic fibrosis and a stroke","volume":"54","author":"Playfor","year":"1999","journal-title":"Thorax"},{"key":"2025082703052828000_14.5.e242302.4","doi-asserted-by":"publisher","DOI":"10.4065\/75.10.1100"},{"key":"2025082703052828000_14.5.e242302.5","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10198"},{"key":"2025082703052828000_14.5.e242302.6","first-page":"293","article-title":"Paradoxical embolization in an adult cystic fibrosis patient","volume":"14","author":"Al Lawati","year":"2007","journal-title":"Can Respir J"},{"key":"2025082703052828000_14.5.e242302.7","doi-asserted-by":"crossref","DOI":"10.4076\/1752-1947-3-8582","article-title":"A woman with cystic fibrosis, severe hypoxaemia, an atrial thrombus and a patent foramen ovale: a case report","volume":"3","author":"Simmonds","year":"2009","journal-title":"J Med Case Rep"},{"key":"2025082703052828000_14.5.e242302.8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fped.2014.00117","article-title":"Increased vigilance needed for the detection of thrombotic complications of central venous access in adolescent cystic fibrosis patients","volume":"2","author":"Kandamany","year":"2014","journal-title":"Front Pediatr"},{"key":"2025082703052828000_14.5.e242302.9","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1093\/eurheartj\/ehy649","article-title":"European position paper on the management of patients with patent foramen ovale. 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