{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:47:05Z","timestamp":1767908825453,"version":"3.49.0"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,15]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Wolcott-Rallison syndrome (WRS), the most common cause of permanent neonatal diabetes mellitus (DM) in consanguineous families, has a poor prognosis, with a mean survival of 5.8 years. Majority of children with WRS succumb to the disease in the first decade of life. We present the long-term follow-up of an 8-year-2-month-old girl with genetically proven WRS who was born to a non-consanguineous parentage. She is on basal bolus regimen of insulin therapy for DM. In addition, she was noted to have features of skeletal dysplasia at 3 years and 3 months of age, which has led to her short stature. Surprisingly, she has had no episodes of hepatitis or liver dysfunction so far, which is frequently seen in children with WRS. To the best of our knowledge, she is the oldest surviving patient with WRS reported in India and South Asia.<\/jats:p>","DOI":"10.1136\/bcr-2021-242376","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T13:11:59Z","timestamp":1620911519000},"page":"e242376","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Long-term follow-up of a child with Wolcott-Rallison syndrome"],"prefix":"10.1136","volume":"14","author":[{"given":"Nikhil","family":"Shah","sequence":"first","affiliation":[{"name":"Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hopsital, Pune, Maharashtra, India"},{"name":"Paediatrics, Cloudnine Hopsital, Malad, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhura Bharat","family":"Karguppikar","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hopsital, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaman","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hopsital, Pune, Maharashtra, India"},{"name":"Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-3235","authenticated-orcid":false,"given":"Anuradha","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hopsital, Pune, Maharashtra, India"},{"name":"Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"2025082622463373000_14.5.e242376.1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1137"},{"key":"2025082622463373000_14.5.e242376.2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2301"},{"key":"2025082622463373000_14.5.e242376.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80596-1"},{"key":"2025082622463373000_14.5.e242376.4","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-1"},{"key":"2025082622463373000_14.5.e242376.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00591.x"},{"key":"2025082622463373000_14.5.e242376.6","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.7.1876"},{"key":"2025082622463373000_14.5.e242376.7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4274\/jcrpe.galenos.2020.2020.0093","article-title":"Genotype and phenotype heterogeneity in 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