{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:36:05Z","timestamp":1787016965681,"version":"build-2736575974"},"reference-count":7,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,6,15]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Isolated optic neuropathy due to folate deficiency is rarely reported. Poor dietary practices, malabsorption, and tobacco\/alcohol abuse are usually responsible. We examined a patient with blinding optic neuropathies and isolated folic acid deficiency. Visual acuity recovered after folate replacement. At the same time, serological investigation revealed high ferritin and iron saturation levels with negative genetic markers for haemochromatosis consistent with the diagnosis of iron overload syndrome. There are no reports of blindness associated with iron overload syndrome.<\/jats:p>","DOI":"10.1136\/bcr-2021-242399","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:54:51Z","timestamp":1627559691000},"page":"e242399","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Isolated optic neuropathy due to folate deficiency with associated iron overload"],"prefix":"10.1136","volume":"14","author":[{"given":"Karina","family":"Pique","sequence":"first","affiliation":[{"name":"Clinical Sciences, Florida State University, Tallahassee, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Taber","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Thompson","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-1646","authenticated-orcid":false,"given":"Charles Gerry","family":"Maitland","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"2025082723023516000_14.7.e242399.1","doi-asserted-by":"crossref","DOI":"10.1186\/1752-1947-2-299","article-title":"Folic acid deficiency optic neuropathy: a case report","volume":"2","author":"de Silva","year":"2008","journal-title":"J Med Case Rep"},{"key":"2025082723023516000_14.7.e242399.2","first-page":"5","article-title":"The metabolic processes of folic acid and vitamin B12 deficiency","volume":"1","author":"Mahmood","year":"2014","journal-title":"Journal of Health Research and Reviews"},{"key":"2025082723023516000_14.7.e242399.3","doi-asserted-by":"publisher","DOI":"10.1159\/000048300"},{"key":"2025082723023516000_14.7.e242399.4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00041327-199409000-00008","article-title":"Folate-Responsive optic neuropathy","volume":"14","author":"Golnik","year":"1994","journal-title":"J Neuroophthalmol"},{"key":"2025082723023516000_14.7.e242399.5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1620\/tjem.86.301","article-title":"Folic acid deficiency in hemochromatosis: probably due to a defective storage of folic acid in the liver","volume":"86","author":"Arakawa","year":"1965","journal-title":"Tohoku J Exp Med"},{"key":"2025082723023516000_14.7.e242399.6","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuv107"},{"key":"2025082723023516000_14.7.e242399.7","doi-asserted-by":"crossref","first-page":"1090.2","DOI":"10.1212\/01.wnl.0000471972.90236.b6","article-title":"Clinicopathologic features of folate-deficiency neuropathy","volume":"85","author":"Sechi","year":"2015","journal-title":"Neurology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-242399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:02:43Z","timestamp":1756360963000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-242399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":7,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,29]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1136\/bcr-2021-242399"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-242399","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}