{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:49:07Z","timestamp":1780890547742,"version":"3.54.1"},"reference-count":23,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,8]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>We report a case of a previously healthy woman in her early 70s who presented with 2 weeks of episodic abdominal pain and significant weight loss. Imaging of her abdomen revealed acute right ovarian torsion associated with bilateral ovarian enlargement and an indeterminant pelvic mass. An urgent laparoscopic bilateral oophorectomy was performed with pathological results consistent with triple-hit high-grade B-cell lymphoma. She was successfully treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab, intrathecal methotrexate and venetoclax with complete remission after three cycles. Ovarian lymphoma is a rare entity and its genetic features have not been well described. We performed a literature review, describe the current knowledge regarding ovarian lymphoma and its therapeutic implication in the genomic age.<\/jats:p>","DOI":"10.1136\/bcr-2021-242423","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T12:17:32Z","timestamp":1622463452000},"page":"e242423","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Triple-hit high-grade B-cell lymphoma presenting with ovarian torsion"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct03984448","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct03984448","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct03984448","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Soravis","family":"Osataphan","sequence":"first","affiliation":[{"name":"Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Augustynowicz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Perrino","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mount Auburn Hospital, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prudence","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"2025082708432388000_14.5.e242423.1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197408)34:2<397::AID-CNCR2820340225>3.0.CO;2-0"},{"key":"2025082708432388000_14.5.e242423.2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.12659\/AJCR.882997","article-title":"Ovary involvement of diffuse large B-cell lymphoma","volume":"13","author":"Hu","year":"2012","journal-title":"Am J Case Rep"},{"key":"2025082708432388000_14.5.e242423.3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1471-0528.1988.tb06611.x","article-title":"Malignant lymphoma presenting as an ovarian tumour: a clinicopathological analysis of 34 cases","volume":"95","author":"Fox","year":"1988","journal-title":"Br J Obstet Gynaecol"},{"key":"2025082708432388000_14.5.e242423.4","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199302000-00007"},{"key":"2025082708432388000_14.5.e242423.5","first-page":"200","volume-title":"Non-Hodgkin\u2019s Lymphoma Involving the Gynecologic Tract: A Review of 88","volume":"8","author":"Vang","year":"2001"},{"key":"2025082708432388000_14.5.e242423.6","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s12032-010-9578-0","article-title":"Clinical features and treatment outcomes of 14 cases of primary ovarian non-Hodgkin's lymphoma: a single-center experience","volume":"28","author":"Zhao","year":"2011","journal-title":"Med Oncol"},{"key":"2025082708432388000_14.5.e242423.7","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12982"},{"key":"2025082708432388000_14.5.e242423.8","first-page":"45","article-title":"[Non-Hodgkin's B-lymphoma of the ovaries with an unfavourable prognosis - incidental finding during caesarean section]","volume":"83","author":"Kop\u00e1\u010dkov\u00e1","year":"2018","journal-title":"Ceska Gynekol"},{"key":"2025082708432388000_14.5.e242423.9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.prp.2017.12.017","article-title":"Genomic analysis reveals distinct subtypes in two rare cases of primary ovarian lymphoma","volume":"214","author":"Khattar","year":"2018","journal-title":"Pathol Res Pract"},{"key":"2025082708432388000_14.5.e242423.10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-673236"},{"key":"2025082708432388000_14.5.e242423.11","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.4583"},{"key":"2025082708432388000_14.5.e242423.12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"2025082708432388000_14.5.e242423.13","unstructured":"Swerdlow S , Carpo E , Harris N . 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