{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:24:59Z","timestamp":1780543499986,"version":"3.54.1"},"reference-count":29,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,19]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Postural orthostatic tachycardia syndrome (POTS) is a common condition of orthostatic intolerance in response to changes in position. We report a case of a middle-aged woman presenting with a new onset of POTS likely due to chemotherapy for treatment of breast cancer. She was started on a trial of a beta blocker, which was effective in controlling her symptoms and heart rate. The objective of this report was to encourage clinicians to consider POTS as a differential diagnosis, while managing patients with symptoms of orthostatic intolerance.<\/jats:p>","DOI":"10.1136\/bcr-2021-242472","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T12:25:53Z","timestamp":1628166353000},"page":"e242472","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Postural orthostatic tachycardia syndrome (POTS) occurring during treatment for breast cancer"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9103-6604","authenticated-orcid":false,"given":"Deshveer","family":"Babra","sequence":"first","affiliation":[{"name":"Acute Medicine, Watford General Hospital, Watford, Hertfordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhyun","family":"Youn","sequence":"additional","affiliation":[{"name":"Acute Medicine, Watford General Hospital, Watford, Hertfordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senan","family":"Devendra","sequence":"additional","affiliation":[{"name":"Acute Medicine, Watford General Hospital, Watford, Hertfordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"2025082710094120000_14.8.e242472.1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/joim.12852","article-title":"Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management","volume":"285","author":"Fedorowski","year":"2019","journal-title":"J Intern Med"},{"key":"2025082710094120000_14.8.e242472.2","first-page":"357","article-title":"Canadian cardiovascular Society position statement on postural orthostatic tachycardia syndrome (POTS) and related disorders of chronic orthostatic intolerance","volume":"36","author":"Raj","year":"2020","journal-title":"Can J Cardiol"},{"key":"2025082710094120000_14.8.e242472.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.029"},{"key":"2025082710094120000_14.8.e242472.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.059"},{"key":"2025082710094120000_14.8.e242472.5","first-page":"519","article-title":"Postural tachycardia syndrome (POTS)","volume":"45","author":"Low","year":"1995","journal-title":"Neurology"},{"key":"2025082710094120000_14.8.e242472.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.761643"},{"key":"2025082710094120000_14.8.e242472.7","doi-asserted-by":"publisher","DOI":"10.4065\/82.3.308"},{"key":"2025082710094120000_14.8.e242472.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009213431204"},{"key":"2025082710094120000_14.8.e242472.9","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp12X648963"},{"key":"2025082710094120000_14.8.e242472.10","doi-asserted-by":"crossref","unstructured":"Grubb BP , Row P , Calkins H . Postural tachycardia, orthostatic intolerance and the chronic fatigue syndrome. In: Grubb BP , Olshansky B , eds. Syncope: mechanisms and management. 2nd ed. Malden, Mass: Blackwell\/Future Press, 2005: 225\u201344.","DOI":"10.1002\/9780470994801.ch13"},{"key":"2025082710094120000_14.8.e242472.11","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1536\/ihj.17-628","article-title":"Postural orthostatic tachycardia in a patient with type 2 diabetes with diabetic neuropathy","volume":"59","author":"Tomichi","year":"2018","journal-title":"Int Heart J"},{"key":"2025082710094120000_14.8.e242472.12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/jpc.12243","article-title":"Postural orthostatic tachycardia syndrome (POTS) in a child with type 1 diabetes","volume":"49","author":"Su","year":"2013","journal-title":"J Paediatr Child Health"},{"key":"2025082710094120000_14.8.e242472.13","doi-asserted-by":"crossref","unstructured":"Graham U , Ritchie KM . Postural orthostatic tachycardia syndrome. BMJ Case Rep 2009. [Epub ahead of print: Epub 2009 Apr 20].","DOI":"10.1136\/bcr.10.2008.1132"},{"key":"2025082710094120000_14.8.e242472.14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.autneu.2018.04.008","article-title":"Pharmacotherapy for postural tachycardia syndrome","volume":"215","author":"Miller","year":"2018","journal-title":"Auton Neurosci"},{"key":"2025082710094120000_14.8.e242472.15","unstructured":"Ferrar M , Sheridan P , West J . Pots UK: postural tachycardia syndrome. A guide for medical professionals. Available: https:\/\/www.potsuk.org\/UserFiles\/File\/MPIL2_Medical_professionals_guide_to_POTSJW.pdf [Accessed 7 Feb 2021]."},{"key":"2025082710094120000_14.8.e242472.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2011.03047.x"},{"key":"2025082710094120000_14.8.e242472.17","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10556"},{"key":"2025082710094120000_14.8.e242472.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023009"},{"key":"2025082710094120000_14.8.e242472.19","article-title":"Postural orthostatic tachycardia syndrome and its unusual presenting complaints in women: a literature minireview","volume":"10","author":"Anjum","year":"2018","journal-title":"Cureus"},{"key":"2025082710094120000_14.8.e242472.20","first-page":"a540","article-title":"Postural orthostatic tachycardia syndrome (POTS): evaluation and management","volume":"5","author":"Conner","year":"2012","journal-title":"BJMP"},{"key":"2025082710094120000_14.8.e242472.21","first-page":"11","article-title":"Quantitative assessment of cardiovascular autonomic impairment in cancer survivors: a single center case series","volume":"6","author":"Noor","year":"2020","journal-title":"Cardiooncology"},{"key":"2025082710094120000_14.8.e242472.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.02.002"},{"key":"2025082710094120000_14.8.e242472.23","first-page":"13","article-title":"Trastuzumab-Mediated cardiotoxicity: current understanding, challenges, and frontiers","volume":"1","author":"Mohan","year":"2018","journal-title":"Antib Ther"},{"key":"2025082710094120000_14.8.e242472.24","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.12688\/f1000research.8053.1","article-title":"Chemotherapy-Induced peripheral neuropathy: an update on the current understanding","volume":"5","author":"Addington","year":"2016","journal-title":"F1000Res"},{"key":"2025082710094120000_14.8.e242472.25","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-015-1418-3","article-title":"Impact of cancer and chemotherapy on autonomic nervous system function and cardiovascular reactivity in young adults with cancer: a case-controlled feasibility study","volume":"15","author":"Adams","year":"2015","journal-title":"BMC Cancer"},{"key":"2025082710094120000_14.8.e242472.26","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1993.1287"},{"key":"2025082710094120000_14.8.e242472.27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/843019","article-title":"Neurotoxicity caused by the treatment with platinum analogues","volume":"2011","author":"Amptoulach","year":"2011","journal-title":"Chemother Res Pract"},{"key":"2025082710094120000_14.8.e242472.28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.HYP.0000158260.46156.b7","article-title":"The causes of postural cardiovascular disorders","volume":"45","author":"Ziegler","year":"2005","journal-title":"Hypertension"},{"key":"2025082710094120000_14.8.e242472.29","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1994.tb04977.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-242472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:09:49Z","timestamp":1756314589000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-242472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,5]]},"published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1136\/bcr-2021-242472"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-242472","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}