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We report a case of PISCL and discuss the challenges faced on diagnosis, namely the impact of corticosteroids on histological findings, the usefulness of MRI, positron-emission tomography\/CT (PET\/CT) and repeated lumbar punctures.<\/jats:p>","DOI":"10.1136\/bcr-2021-242548","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T13:49:31Z","timestamp":1621432171000},"page":"e242548","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Primary intramedullary spinal-cord lymphoma (PISCL): a rare entity with a challenging diagnosis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-7761","authenticated-orcid":false,"given":"Emanuel Santos","family":"Martins","sequence":"first","affiliation":[{"name":"Neurology, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Duque","sequence":"additional","affiliation":[{"name":"Neurology, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olinda","family":"Rebelo","sequence":"additional","affiliation":[{"name":"Neurology, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f3nia","family":"Batista","sequence":"additional","affiliation":[{"name":"Neurology, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"2025082700113007000_14.5.e242548.1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1177\/0284185118809540","article-title":"Intramedullary spinal tumor-like lesions","volume":"60","author":"Maj","year":"2019","journal-title":"Acta Radiol"},{"key":"2025082700113007000_14.5.e242548.2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1212\/CON.0000000000000900","article-title":"Myelitis and other autoimmune Myelopathies","volume":"27","author":"Lopez Chiriboga","year":"2021","journal-title":"Continuum"},{"key":"2025082700113007000_14.5.e242548.3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1212\/CON.0000000000000964","article-title":"Neoplastic Myelopathies","volume":"27","author":"Pruitt","year":"2021","journal-title":"Continuum"},{"key":"2025082700113007000_14.5.e242548.4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822b00b9"},{"key":"2025082700113007000_14.5.e242548.5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30965"},{"key":"2025082700113007000_14.5.e242548.6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.critrevonc.2017.03.019","article-title":"Primary central nervous system lymphoma","volume":"113","author":"Citterio","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"key":"2025082700113007000_14.5.e242548.7","first-page":"1","article-title":"Primary central nervous system lymphomas","volume":"113","author":"Oya","year":"2017","journal-title":"Radiat Ther Extranodal Lymphomas"},{"key":"2025082700113007000_14.5.e242548.8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1017\/cjn.2016.255","article-title":"The influence of corticosteroids on diagnostic accuracy of biopsy for primary central nervous system lymphoma","volume":"43","author":"Binnahil","year":"2016","journal-title":"Can J Neurol Sci"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-242548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:11:39Z","timestamp":1756278699000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-242548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,19]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/bcr-2021-242548"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-242548","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}