{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T19:00:54Z","timestamp":1772218854778,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,9,13]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Eosinophilia can occur due to a plethora of allergic, infective, neoplastic and idiopathic conditions. Hypereosinophilic syndrome (HES) is characterised by sustained eosinophilia and multiorgan dysfunction in the absence of an identifiable cause. It may range from a self-limiting condition to a rapidly progressive life-threatening disorder, of which ischaemic stroke is a rare presentation. Such episodes can rarely be the presenting manifestation, and may develop before any other laboratory abnormality or organ involvement. We report a case of HES presented with multiorgan (neurological and renal) involvement, managed successfully with steroids and cytoreductive therapy. High initial absolute eosinophil count can be a clue to the diagnosis and early treatment should be initiated in such patients, to prevent fatal outcomes.<\/jats:p>","DOI":"10.1136\/bcr-2021-242619","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T10:33:21Z","timestamp":1633084401000},"page":"e242619","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Hypereosinophilia: a rare cause of stroke and multiorgan dysfunction"],"prefix":"10.1136","volume":"14","author":[{"given":"Kapil L","family":"Barbind","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Army Hospital Research and Referral, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-8809","authenticated-orcid":false,"given":"Revanth","family":"Boddu","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology, Army Hospital Research and Referral, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KP","family":"Shijith","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Army Hospital Research and Referral, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6325-2972","authenticated-orcid":false,"given":"Kundan","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology, Army Hospital Research and Referral, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"2025082706563823000_14.10.e242619.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197501000-00001"},{"key":"2025082706563823000_14.10.e242619.2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/ajh.25617","article-title":"World health Organization-defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management","volume":"94","author":"Shomali","year":"2019","journal-title":"Am J Hematol"},{"key":"2025082706563823000_14.10.e242619.3","first-page":"2316","article-title":"Hypereosinophilia-an unusual cause of multiple embolic strokes and multi-organ dysfunction","volume":"7","author":"Khwaja","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"2025082706563823000_14.10.e242619.4","first-page":"184","article-title":"Hypereosinophilic syndrome with recurrent strokes: a case report","volume":"17","author":"Chang","year":"2008","journal-title":"Acta Neurol Taiwan"},{"key":"2025082706563823000_14.10.e242619.5","doi-asserted-by":"publisher","DOI":"10.1159\/000113864"},{"key":"2025082706563823000_14.10.e242619.6","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V83.10.2759.2759","article-title":"The idiopathic hypereosinophilic syndrome","volume":"83","author":"Weller","year":"1994","journal-title":"Blood"},{"key":"2025082706563823000_14.10.e242619.7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2152"},{"key":"2025082706563823000_14.10.e242619.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.022"},{"key":"2025082706563823000_14.10.e242619.9","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2012.01.001"},{"key":"2025082706563823000_14.10.e242619.10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.12998\/wjcc.v4.i10.328","article-title":"Idiopathic hypereosinophilic syndrome presenting with severe vasculitis successfully treated with imatinib","volume":"4","author":"Fraticelli","year":"2016","journal-title":"World J Clin Cases"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-242619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T13:56:43Z","timestamp":1756303003000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-242619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":10,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10,1]]},"published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1136\/bcr-2021-242619"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-242619","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}