{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:39:32Z","timestamp":1761514772834,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,25]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Hypereosinophilic syndrome (HES) is a rare haematologic disorder characterised by unexplained, persistent eosinophilia with organ involvement. We report the case of a 74-year-old patient who presented with a pemphigoid-like bullous rash as the only manifestation of an HES. This report highlights the importance of the dermatological manifestations of this potentially life-threating condition that may initially present as a skin-limited disease. Bullous pemphigoid (BP) is a very common autoimmune blistering dermatosis that may share common clinical and histological features or associate with an HES. HES should be considered when patients diagnosed with BP demonstrate atypical course under corticosteroids and\/or recalcitrant blood eosinophilia.<\/jats:p>","DOI":"10.1136\/bcr-2021-242695","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T12:37:14Z","timestamp":1623155834000},"page":"e242695","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Bullous pemphigoid-like rash revealing hypereosinophilic syndrome"],"prefix":"10.1136","volume":"14","author":[{"given":"Mehdi","family":"Khallaayoune","sequence":"first","affiliation":[{"name":"Department of Dermatology, Mohammed V University of Rabat, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"Sialiti","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mohammed V University of Rabat, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariame","family":"Meziane","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mohammed V University of Rabat, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karima","family":"Senouci","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mohammed V University of Rabat, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"2025082712554786000_14.6.e242695.1","doi-asserted-by":"crossref","first-page":"e424","DOI":"10.1111\/1346-8138.15021","article-title":"Pemphigus foliaceus progressing to bullous pemphigoid","volume":"46","author":"Iwakura","year":"2019","journal-title":"J Dermatol"},{"key":"2025082712554786000_14.6.e242695.2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1177\/1203475418773359","article-title":"Bullous pemphigoid: a 10-year study of discordant results on direct immunofluorescence","volume":"22","author":"Fudge","year":"2018","journal-title":"J Cutan Med Surg"},{"key":"2025082712554786000_14.6.e242695.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)80035-9"},{"key":"2025082712554786000_14.6.e242695.4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1001\/jamadermatol.2018.4390","article-title":"Assessment of diagnostic strategy for early recognition of bullous and nonbullous variants of pemphigoid","volume":"155","author":"Meijer","year":"2019","journal-title":"JAMA Dermatol"},{"key":"2025082712554786000_14.6.e242695.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011592"},{"key":"2025082712554786000_14.6.e242695.6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20423"},{"key":"2025082712554786000_14.6.e242695.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"2025082712554786000_14.6.e242695.8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1440-0960.2009.00610.x","article-title":"Isolated symptomatic cutaneous disease in hypereosinophilic syndrome","volume":"51","author":"Preda","year":"2010","journal-title":"Australas J Dermatol"},{"key":"2025082712554786000_14.6.e242695.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.042"},{"key":"2025082712554786000_14.6.e242695.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.07.009"},{"key":"2025082712554786000_14.6.e242695.11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11882-012-0241-z","article-title":"Clinical overview of cutaneous features in hypereosinophilic syndrome","volume":"12","author":"Pl\u00f6tz","year":"2012","journal-title":"Curr Allergy Asthma Rep"},{"key":"2025082712554786000_14.6.e242695.12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/s00105-004-0851-z","article-title":"[Hypereosinophilic dermatitis. An overlooked diagnosis?]","volume":"56","author":"Kemmler","year":"2005","journal-title":"Hautarzt"},{"key":"2025082712554786000_14.6.e242695.13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/1346-8138.14888","article-title":"Pemphigus-like hypereosinophilic syndrome with FIP1L1-PDGFRA fusion gene: a challenging and uncommon clinical presentation","volume":"46","author":"Curto-Barredo","year":"2019","journal-title":"J Dermatol"},{"key":"2025082712554786000_14.6.e242695.14","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/j.jaad.2006.02.059","article-title":"Bullous pemphigoid associated with hypereosinophilic syndrome: simultaneous response to imatinib","volume":"56","author":"Hofmann","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"2025082712554786000_14.6.e242695.15","first-page":"4S165","article-title":"Pemphigoide et syndrome hyper\u00e9osinophilique d'\u00e9volution fatale","volume":"127","author":"Gscheidel","year":"2000","journal-title":"Ann Dermatol Venereol"},{"key":"2025082712554786000_14.6.e242695.16","first-page":"1291","article-title":"[Idiopathic hypereosinophilic syndrome and bullous pemphigoid]","volume":"129","author":"Belgnaoui","year":"2002","journal-title":"Ann Dermatol Venereol"},{"key":"2025082712554786000_14.6.e242695.17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00105-005-0940-7","article-title":"[Pemphigoid nodularis triggered by hypereosinophilic syndrome?]","volume":"57","author":"von Felbert","year":"2006","journal-title":"Hautarzt"},{"key":"2025082712554786000_14.6.e242695.18","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1365-2133.2000.03750.x","article-title":"Hypereosinophilic dermatosis: skin lesions as the only manifestation of the idiopathic hypereosinophilic syndrome?","volume":"143","author":"Offidani","year":"2000","journal-title":"Br J Dermatol"},{"key":"2025082712554786000_14.6.e242695.19","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.6.601"},{"key":"2025082712554786000_14.6.e242695.20","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jaip.2017.08.001","article-title":"Biologic agents for the treatment of hypereosinophilic syndromes","volume":"5","author":"Kuang","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025082712554786000_14.6.e242695.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.022"},{"key":"2025082712554786000_14.6.e242695.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.055"},{"key":"2025082712554786000_14.6.e242695.23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jid.2016.10.044","article-title":"Treatment of hypereosinophilic syndrome with cutaneous involvement with the JAK inhibitors tofacitinib and ruxolitinib","volume":"137","author":"King","year":"2017","journal-title":"J Invest Dermatol"},{"key":"2025082712554786000_14.6.e242695.24","doi-asserted-by":"publisher","DOI":"10.1159\/000085560"},{"key":"2025082712554786000_14.6.e242695.25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/ajh.24196","article-title":"World health Organization-defined eosinophilic disorders: 2015 update on diagnosis, risk stratification, and management","volume":"90","author":"Gotlib","year":"2015","journal-title":"Am J Hematol"},{"key":"2025082712554786000_14.6.e242695.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.12.016"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-242695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:55:56Z","timestamp":1756324556000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-242695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6,8]]},"published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1136\/bcr-2021-242695"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-242695","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}