{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:08:50Z","timestamp":1781874530855,"version":"3.54.5"},"reference-count":8,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,5]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Adrenocortical carcinoma (ACC) is a rare malignancy, with an estimated annual incidence of 0.7\u20132 cases per million and a median overall survival of 3\u20134 years. Hormone-secreting ACCs represent most cases; of these, only a small minority presents with virilisation alone. Early diagnosis is key to increase the chances of a better outcome. Here, we report a case of a 41-year-old woman who presented with menstrual irregularities, hirsutism and virilising symptoms, associated with abdominal discomfort and constitutional symptoms. On physical examination, there was a palpable mass in the right upper quadrant. Laboratory workup revealed elevated serum androgens. The imaging study showed a 163\u00d7110\u00d7122\u2009cm right adrenal mass with features consistent with ACC and suggested potential hepatic invasion. Our patient underwent surgical resection, and the histopathological findings confirmed the diagnosis. She was referred to a specialised centre for follow-up and adjuvant therapy.<\/jats:p>","DOI":"10.1136\/bcr-2021-242895","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:13:16Z","timestamp":1622679196000},"page":"e242895","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Virilising adrenocortical carcinoma"],"prefix":"10.1136","volume":"14","author":[{"given":"Diogo Nunes","family":"Correia","sequence":"first","affiliation":[{"name":"Universidade Nova de Lisboa Faculdade de Ci\u00eancias M\u00e9dicas, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas Redondo de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Nova de Lisboa Faculdade de Ci\u00eancias M\u00e9dicas, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeenal Assuani","family":"Mangi","sequence":"additional","affiliation":[{"name":"Universidade Nova de Lisboa Faculdade de Ci\u00eancias M\u00e9dicas, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"2025082701225383000_14.6.e242895.1","doi-asserted-by":"crossref","DOI":"10.1007\/s11912-019-0773-7","article-title":"Management of adrenocortical carcinoma","volume":"21","author":"Jasim","year":"2019","journal-title":"Curr Oncol Rep"},{"key":"2025082701225383000_14.6.e242895.2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3390\/biomedicines8120551","article-title":"Medical approaches in adrenocortical carcinoma","volume":"8","author":"Paragliola","year":"2020","journal-title":"Biomedicines"},{"key":"2025082701225383000_14.6.e242895.3","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-18-0608","article-title":"European Society of endocrinology clinical practice guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European network for the study of adrenal tumors","volume":"179","author":"Fassnacht","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"2025082701225383000_14.6.e242895.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64023-2"},{"key":"2025082701225383000_14.6.e242895.5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000494906","article-title":"Androgen-Secreting ovarian tumors","volume":"53","author":"Macut","year":"2019","journal-title":"Front Horm Res"},{"key":"2025082701225383000_14.6.e242895.6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.vh.2018.02.002","article-title":"Dehydroepiandrosterone research: past, current, and future","volume":"108","author":"Klinge","year":"2018","journal-title":"Vitam Horm"},{"key":"2025082701225383000_14.6.e242895.7","doi-asserted-by":"publisher","DOI":"10.1210\/er.2013-1029"},{"key":"2025082701225383000_14.6.e242895.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.03.010"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-242895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:23:04Z","timestamp":1756282984000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-242895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":8,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6,2]]},"published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1136\/bcr-2021-242895"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-242895","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}