{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:12:52Z","timestamp":1783912372550,"version":"3.55.0"},"reference-count":22,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,8]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Essential thrombocythemia (ET)-related acute ischaemic stroke (AIS) may account for approximately 0.25%\u20130.5% of all ischaemic strokes. If left undiagnosed and untreated, patients with ET carry an increased risk of recurrent thrombosis involving major organs including the brain. We report an interesting case of a 67-year-old man, who was successfully thrombolysed for AIS resulting from ET. He presented with sudden onset of left-sided hemiparesis with a left-ventricular clot. His subsequent investigations including positive JAK2 V617F mutation confirmed the diagnosis of ET. He made a significant recovery with thrombolysis, anticoagulation, antiplatelet and hydroxyurea. A fear of post-thrombolytic haemorrhagic complications appears the major reason for the lack of reports of thrombolysis in ET-related AIS. Although the diagnosis of ET was confirmed on subsequent investigations, successful thrombolysis in our case provides preliminary evidence that ET-related AIS cases can undergo successful thrombolysis using tenecteplase. To date, ours is only the second case of ET-related AIS being thrombolysed.<\/jats:p>","DOI":"10.1136\/bcr-2021-242925","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T13:50:03Z","timestamp":1621432203000},"page":"e242925","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Successful thrombolysis in essential thrombocythemia-related acute ischaemic stroke"],"prefix":"10.1136","volume":"14","author":[{"given":"Ishita","family":"Desai","sequence":"first","affiliation":[{"name":"Neurology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Neurology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mritunjai Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Neurology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Neurology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"2025082801270000000_14.5.e242925.1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1590\/1806-9282.65.6.772","article-title":"Essential thrombocythemia - a predisponent factor for stroke","volume":"65","author":"Batista","year":"2019","journal-title":"Rev Assoc Med Bras"},{"key":"2025082801270000000_14.5.e242925.2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jns.2013.10.016","article-title":"Stroke in essential thrombocythemia","volume":"336","author":"P\u00f3sfai","year":"2014","journal-title":"J Neurol Sci"},{"key":"2025082801270000000_14.5.e242925.3","doi-asserted-by":"crossref","DOI":"10.1097\/MAJ.0000000000000497","article-title":"Essential thrombocythemia-related stroke and improvement with tissue plasminogen activator","volume":"350","author":"Chen","year":"2015","journal-title":"Am J Med Sci"},{"key":"2025082801270000000_14.5.e242925.4","doi-asserted-by":"crossref","unstructured":"Tefferi A , Vannucchi AM , Barbui T . Essential thrombocythemia treatment algorithm 2018. Blood Cancer J 2018;8.doi:10.1038\/s41408-017-0041-8","DOI":"10.1038\/s41408-017-0041-8"},{"key":"2025082801270000000_14.5.e242925.5","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-018-0054-y","article-title":"The 2016 who classification and diagnostic criteria for myeloproliferative neoplasms: document summary and in-depth discussion","volume":"8","author":"Barbui","year":"2018","journal-title":"Blood Cancer J"},{"key":"2025082801270000000_14.5.e242925.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"2025082801270000000_14.5.e242925.7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1753944717711139","article-title":"Challenges in management of left ventricular thrombus","volume":"11","author":"Habash","year":"2017","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"2025082801270000000_14.5.e242925.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05277.x"},{"key":"2025082801270000000_14.5.e242925.9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-949664"},{"key":"2025082801270000000_14.5.e242925.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03183.x"},{"key":"2025082801270000000_14.5.e242925.11","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s10072-020-04247-2","article-title":"Recurrent stereotyped TIAs: atypical bow Hunter's syndrome due to compression of non-dominant vertebral artery terminating in pica","volume":"41","author":"Di Stefano","year":"2020","journal-title":"Neurol Sci"},{"key":"2025082801270000000_14.5.e242925.12","doi-asserted-by":"crossref","DOI":"10.1007\/s10072-020-05018-9","article-title":"Fetal variant of posterior cerebral artery: just a physiologic variant or a window for possible ischemic stroke?","author":"Di Pietro","year":"2021","journal-title":"Neurol Sci"},{"key":"2025082801270000000_14.5.e242925.13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3171\/2018.2.JNS1832","article-title":"Rete middle cerebral artery anomalies: a unifying name, case series, and literature review","volume":"131","author":"Cho","year":"2019","journal-title":"J Neurosurg"},{"key":"2025082801270000000_14.5.e242925.14","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.478685"},{"key":"2025082801270000000_14.5.e242925.15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2641"},{"key":"2025082801270000000_14.5.e242925.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00500-X"},{"key":"2025082801270000000_14.5.e242925.17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"2025082801270000000_14.5.e242925.18","doi-asserted-by":"crossref","unstructured":"De Angelis MV , Di Stefano V , Franciotti R , et al . Cryptogenic stroke and atrial fibrillation in a real-world population: the role of insertable cardiac monitors. Sci Rep 2020;10.doi:10.1038\/s41598-020-60180-6","DOI":"10.1038\/s41598-020-60180-6"},{"key":"2025082801270000000_14.5.e242925.19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.12.012","article-title":"Ischemic stroke with essential thrombocythemia: a case series","volume":"24","author":"Kato","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2025082801270000000_14.5.e242925.20","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/01.STR.26.8.1463","article-title":"Ischemic stroke as first manifestation of essential thrombocythemia. Report of six cases","volume":"26","author":"Arboix","year":"1995","journal-title":"Stroke"},{"key":"2025082801270000000_14.5.e242925.21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03183.x"},{"key":"2025082801270000000_14.5.e242925.22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.116820","article-title":"Paradoxical embolism through a patent foramen ovale from central venous catheter thrombosis: a potential cause of stroke","volume":"414","author":"Di Stefano","year":"2020","journal-title":"J Neurol Sci"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-242925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:27:12Z","timestamp":1756369632000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-242925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,19]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/bcr-2021-242925"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-242925","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}