{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:25:58Z","timestamp":1788830758936,"version":"build-2803163510"},"reference-count":12,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,8]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>\n                    We report a case of vancomycin-induced thrombocytopenia (VIT) with rapid onset after re-exposure to vancomycin. A 58-year-old man with cellulitis was initiated on vancomycin. Approximately 1\u2009hour into the vancomycin infusion, the patient developed an infusion-related reaction. Vancomycin infusion was stopped. A complete blood count obtained 4\u2009hours after discontinuation of the vancomycin infusion revealed a platelet count of 31 \u00d710\u00ad\n                    <jats:sup>9<\/jats:sup>\n                    \/L. Investigations ruled out likely causes of thrombocytopenia. VIT was diagnosed based on clinical symptoms and confirmed with drug-dependent platelet antibody testing. Without complications, platelet counts recovered within 7 days after discontinuation of vancomycin. No correlation between vancomycin level and VIT was observed.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2021-243027","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T12:41:35Z","timestamp":1627303295000},"page":"e243027","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Rapid onset vancomycin-induced thrombocytopenia confirmed by vancomycin antibody test"],"prefix":"10.1136","volume":"14","author":[{"given":"Thakul","family":"Rattanasuwan","sequence":"first","affiliation":[{"name":"College of Pharmacy, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Marks","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Delaune","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-5263","authenticated-orcid":false,"given":"Adonice P","family":"Khoury","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"2025082709022147000_14.7.e243027.1","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.clinthera.2012.06.013","article-title":"Daptomycin compared to vancomycin for the treatment of osteomyelitis: a single-center, retrospective cohort study","volume":"34","author":"Moenster","year":"2012","journal-title":"Clin Ther"},{"key":"2025082709022147000_14.7.e243027.2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-236"},{"key":"2025082709022147000_14.7.e243027.3","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025082709022147000_14.7.e243027.4","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9072212","article-title":"Pathophysiology and diagnosis of drug-induced immune thrombocytopenia","volume":"9","author":"Vayne","year":"2020","journal-title":"J Clin Med"},{"key":"2025082709022147000_14.7.e243027.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-643148"},{"key":"2025082709022147000_14.7.e243027.6","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.576"},{"key":"2025082709022147000_14.7.e243027.7","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12852"},{"key":"2025082709022147000_14.7.e243027.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065066"},{"key":"2025082709022147000_14.7.e243027.9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40264-016-0469-y","article-title":"Vancomycin-Induced thrombocytopenia: a narrative review","volume":"40","author":"Mohammadi","year":"2017","journal-title":"Drug Saf"},{"key":"2025082709022147000_14.7.e243027.10","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1177\/1060028019867433","article-title":"Rapid-Onset Vancomycin-Induced thrombocytopenia with Reexposure","volume":"53","author":"Getz","year":"2019","journal-title":"Ann Pharmacother"},{"key":"2025082709022147000_14.7.e243027.11","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1002\/phar.1132","article-title":"Vancomycin-induced thrombocytopenia without isolation of a drug-dependent antibody","volume":"32","author":"Ruggero","year":"2012","journal-title":"Pharmacotherapy"},{"key":"2025082709022147000_14.7.e243027.12","article-title":"A case of Vancomycin-Induced immune thrombocytopenia","volume":"12","author":"MacDougall","year":"2020","journal-title":"Cureus"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-243027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:02:29Z","timestamp":1756310549000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-243027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":12,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,26]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1136\/bcr-2021-243027"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-243027","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}