{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:57:52Z","timestamp":1763445472339,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,15]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Non-Hodgkin\u2019s lymphoma (NHL) presenting as a soft tissue sarcoma is rare, occurring at a rate of 0.11%. Peripheral T-cell lymphomas comprise 4% of all NHLs. We report the case of a 49-year-old Caucasian man who presented with a mass in the medial aspect of the thigh. Ultrasound showed a complex subcutaneous mass. MRI demonstrated a superficial complex skeletal mass affecting the sartorius muscle with other lesions involving the femur and the gluteus maximus. Positron emission tomography-computed tomography (PET-CT) showed diffuse pulmonary metastases with no involvement of nodes, liver, spleen with high suspicion of advanced sarcoma. Core biopsy revealed a T-cell NHL, and staining was positive for anaplastic lymphoma kinase. The patient received six cycles of cyclophosphamide, doxorubicin, vincristine, etoposide and prednisone. Repeat PET-CT showed reduction in the mass, with no fluorodeoxyglucose-avid uptake. Latest MRI showed near-normal intensity. Further PET-CTs determine disease remission or progression.<\/jats:p>","DOI":"10.1136\/bcr-2021-243243","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:52:38Z","timestamp":1627559558000},"page":"e243243","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Primary soft tissue sarcoma: stage IV extranodal T-cell non-Hodgkin\u2019s lymphoma"],"prefix":"10.1136","volume":"14","author":[{"given":"Joshua","family":"Christy","sequence":"first","affiliation":[{"name":"Internal Medicine, McLaren Regional Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Kandah","sequence":"additional","affiliation":[{"name":"Internal Medicine, McLaren Regional Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"Kesari","sequence":"additional","affiliation":[{"name":"McLaren Health Care Corp, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatasiva","family":"Peram","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Michigan State University College of Human Medicine, East Lansing, Michigan, USA"},{"name":"Hematolgy\/Oncology, Triumph Cancer Center, Grand Blanc, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"2025082701132891000_14.7.e243243.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198705000-00004"},{"key":"2025082701132891000_14.7.e243243.2","first-page":"850","article-title":"Peripheral T-cell lymphoma presenting as a soft-tissue mass of the extremity","volume":"112","author":"Axiotis","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"2025082701132891000_14.7.e243243.3","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3892\/ol.2012.848","article-title":"Primary giant lymphoma of the right thigh: a case report and brief review of the literature","volume":"4","author":"Gao","year":"2012","journal-title":"Oncol Lett"},{"key":"2025082701132891000_14.7.e243243.4","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.soc.2014.06.006","article-title":"Radiology of soft tissue tumors","volume":"23","author":"Mallinson","year":"2014","journal-title":"Surg Oncol Clin N Am"},{"key":"2025082701132891000_14.7.e243243.5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S1726-4901(09)70382-X","article-title":"Ultrasonographic and Mr findings of alveolar soft part sarcoma","volume":"72","author":"Lai","year":"2009","journal-title":"J Chin Med Assoc"},{"key":"2025082701132891000_14.7.e243243.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03704.x"},{"key":"2025082701132891000_14.7.e243243.7","unstructured":"National Comprehensive Cancer Network . T-cell lymphomas. 1.2021 version. Available: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/t-cell.pdf"},{"key":"2025082701132891000_14.7.e243243.8","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1182\/blood.V96.12.3681","article-title":"CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features","volume":"96","author":"Stein","year":"2000","journal-title":"Blood"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-243243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:13:39Z","timestamp":1756282419000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-243243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":8,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,29]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1136\/bcr-2021-243243"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-243243","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}