{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:27:14Z","timestamp":1783488434755,"version":"3.55.0"},"reference-count":20,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,15]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>We report a case of a 46-year-old woman who presented with a midline neck mass 2\u2009years after total thyroidectomy for Graves\u2019 disease. Despite levothyroxine treatment withdrawal, she remained biochemically with subclinical hyperthyroidism. Her thyroid stimulating hormone receptor antibodies were consistently elevated. Neck ultrasonography revealed an infrahyoid solid nodule and pertechnetate scintigraphy confirmed an increased uptake at the same level, without any uptake in the thyroid bed. Treatment with methimazole 5\u2009mg\/day was initiated with clinical improvement and achievement of euthyroidism. After that, she received 10 mCi of radioactive iodine. Since then, she experienced regression of the neck mass and is doing well on a replacement dose of levothyroxine. Recurrence of Graves\u2019 disease in ectopic thyroid following total thyroidectomy is extremely rare. This diagnose should be considered in patients who underwent total thyroidectomy and remained with thyrotoxicosis despite decreasing the levothyroxine dose.<\/jats:p>","DOI":"10.1136\/bcr-2021-243313","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T11:28:52Z","timestamp":1627385332000},"page":"e243313","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Graves\u2019 disease and recurrence in ectopic thyroid tissue after total thyroidectomy"],"prefix":"10.1136","volume":"14","author":[{"given":"Clara","family":"Cunha","sequence":"first","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Ferrinho","sequence":"additional","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Sequeira","family":"Duarte","sequence":"additional","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"2025082713123770000_14.7.e243313.1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0461"},{"key":"2025082713123770000_14.7.e243313.2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijsu.2014.05.076","article-title":"Morphological, diagnostic and surgical features of ectopic thyroid gland: a review of literature","volume":"12(Suppl 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