{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:40:01Z","timestamp":1756323601981,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"unspecified","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,8,24]]},"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>The most common neurological manifestation of eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is mononeuritis multiplex caused by small-vessel vasculitis. In contrast, central nervous system involvement is rare. Among EGPA-associated central nervous system disorders, there are only a few reported cases of hypertrophic pachymeningitis (HP). Here, we report a patient with EGPA with headache and ophthalmoplegia who presented with HP and had a dural biopsy. The biopsy specimen showed lymphocytic inflammatory cell infiltration without EGPA-specific findings, that is, eosinophilic infiltration, granuloma or angiitis. To the best of our knowledge, there are no previous reports of EGPA-associated HP pathology. Here, we report the first case presentation of a patient with EGPA-associated HP with pathological findings.<\/jats:p>","DOI":"10.1136\/bcr-2021-243395","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T12:06:21Z","timestamp":1632139581000},"page":"e243395","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8528-2622","authenticated-orcid":false,"given":"Wataru","family":"Shiraishi","sequence":"first","affiliation":[{"name":"Department of Neurology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Shiraishi Internal Medicine Clinic, Nogata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"2025082712275272000_14.9.e243395.1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.alit.2019.06.004","article-title":"Update on eosinophilic granulomatosis with polyangiitis","volume":"68","author":"Furuta","year":"2019","journal-title":"Allergol Int"},{"key":"2025082712275272000_14.9.e243395.2","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg","year":"1951","journal-title":"Am J Pathol"},{"key":"2025082712275272000_14.9.e243395.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.002"},{"key":"2025082712275272000_14.9.e243395.4","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.autrev.2017.07.007","article-title":"Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): report of 26 patients and review of the literature","volume":"16","author":"Andr\u00e9","year":"2017","journal-title":"Autoimmun Rev"},{"key":"2025082712275272000_14.9.e243395.5","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000113748.53023.B7"},{"key":"2025082712275272000_14.9.e243395.6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306410"},{"key":"2025082712275272000_14.9.e243395.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330806"},{"key":"2025082712275272000_14.9.e243395.8","doi-asserted-by":"crossref","DOI":"10.1097\/RHU.0000000000000694","article-title":"Development of hypertrophic pachymeningitis in a patient with antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis","volume":"25","author":"Nakano","year":"2019","journal-title":"J Clin Rheumatol"},{"key":"2025082712275272000_14.9.e243395.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(01)00071-2"},{"key":"2025082712275272000_14.9.e243395.10","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.857582"},{"key":"2025082712275272000_14.9.e243395.11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s12026-016-8863-1","article-title":"Idiopathic hypertrophic pachymeningitis: an autoimmune IgG4-related disease","volume":"65","author":"De Virgilio","year":"2017","journal-title":"Immunol Res"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-243395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:27:56Z","timestamp":1756322876000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-243395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9,20]]},"published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1136\/bcr-2021-243395"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-243395","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}