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At 1-month follow-up, he showed complete resolution of ventricular hypertrophy and suspended propranolol. In the literature, of the 22 cases of CDA after intrauterine exposure to diclofenac, 11 resolved in utero, 3 required ventilatory and inotropic support and 1 evolved to persistent pulmonary hypertension. In this case, a thorough anamnesis was key to identify the probable cause of an otherwise unexplained transient ventricular hypertrophy. This case also alerts to the fetal risks of non-steroidal anti-inflammatory drugs during the third trimester, requiring close monitoring.<\/jats:p>","DOI":"10.1136\/bcr-2021-243485","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T12:22:38Z","timestamp":1624537358000},"page":"e243485","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Premature closure of ductus arteriosus after a single dose of diclofenac during pregnancy"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-2462","authenticated-orcid":false,"given":"Constan\u00e7a Soares","family":"dos Santos","sequence":"first","affiliation":[{"name":"Department of Neonatology A, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Portugal"},{"name":"Department of Paediatrics, Centro Hospitalar Cova da Beira EPE, Covilha, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Vaz","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Hospital Pedi\u00e1trico, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Castelo","sequence":"additional","affiliation":[{"name":"Department of Neonatology A, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Tiago","sequence":"additional","affiliation":[{"name":"Department of Neonatology A, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"2025082703263078000_14.6.e243485.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2016.04.001"},{"key":"2025082703263078000_14.6.e243485.2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fped.2018.00140","article-title":"Echocardiographic evaluation of transitional circulation for the neonatologists","volume":"6","author":"Singh","year":"2018","journal-title":"Front Pediatr"},{"key":"2025082703263078000_14.6.e243485.3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.siny.2015.04.003","article-title":"Physiology of the fetal and transitional circulation","volume":"20","author":"Finnemore","year":"2015","journal-title":"Seminars in Fetal and Neonatal Medicine"},{"key":"2025082703263078000_14.6.e243485.4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/00015385.2017.1314876","article-title":"Dysfunction of the foetal arterial duct results in a wide spectrum of cardiovascular pathology","volume":"72","author":"Gewillig","year":"2017","journal-title":"Acta Cardiol"},{"key":"2025082703263078000_14.6.e243485.5","doi-asserted-by":"crossref","DOI":"10.3233\/NPM-15814031","article-title":"Diagnosis and management of fetal ductus arteriosus constriction-closure","author":"Genovese","year":"2015","journal-title":"J Neonatal Perinatal Med"},{"key":"2025082703263078000_14.6.e243485.6","unstructured":"Schjerning A-M , McGettigan P , Gislason G . 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