{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:04:19Z","timestamp":1756339459241,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,7]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>A 37-year-old woman presented with a few days\u2019 history of lower abdominal pain and an incidental finding of hypercalcaemia. A thorough workup ensued, and the cause was found to be an exceptionally rare ovarian tumour\u2014ovarian small cell carcinoma of the hypercalcaemic type. Acute treatment of hypercalcaemia consisted of aggressive intravenous fluids and bisphosphonates. She underwent surgery to remove the tumour and is currently receiving systemic platinum\/etoposide chemotherapy combination to be followed by pelvic radiotherapy. This case highlights the wide range of differential diagnosis for hypercalcaemia and the importance of a stepwise and thorough approach during investigations. We discuss the pathophysiology of malignancy-related hypercalcaemia, focusing especially on parathyroid hormone-related peptide-associated hypercalcaemia.<\/jats:p>","DOI":"10.1136\/bcr-2021-243571","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T10:36:26Z","timestamp":1627641386000},"page":"e243571","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Hypercalcaemia due to ovarian small cell carcinoma of the hypercalcaemic type"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-4233","authenticated-orcid":false,"given":"Annalisa","family":"Montebello","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Mater Dei Hospital, L-Imsida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Gruppetta","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Mater Dei Hospital, L-Imsida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"2025082706543654000_14.7.e243571.1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1055\/a-1049-0647","article-title":"Diagnosis, pathophysiology and management of hypercalcemia in malignancy: a review of the literature","volume":"51","author":"Asonitis","year":"2019","journal-title":"Horm Metab Res"},{"key":"2025082706543654000_14.7.e243571.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0322-z"},{"key":"2025082706543654000_14.7.e243571.3","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1210\/jc.2014-4250","article-title":"PTHrP-mediated hypercalcemia: causes and survival in 138 patients","volume":"100","author":"Donovan","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082706543654000_14.7.e243571.4","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007090981"},{"key":"2025082706543654000_14.7.e243571.5","doi-asserted-by":"crossref","unstructured":"Naafs MAB . Parathyroid hormone related peptide (PTHrP): a mini-review. 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