{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:26:34Z","timestamp":1756463194839,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,1,21]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Receptor conversion in breast cancer occurs in up to 32% of patients, resulting in ineffective therapy in the absence of corresponding biomarkers. We report a case of a middle-aged woman who presented with a 2-month history of hoarseness. Laryngoscopy demonstrated right vocal cord paralysis. Whole body positron emission tomography-CT (PET-CT) scan showed a hypermetabolic cervical lymph node, worrisome for metastasis. Biopsy of the cervical lymph node was consistent with metastatic carcinoma of the breast (GATA3 and mammaglobin positive, oestrogen receptor (OR)-positive, progesterone receptor-negative and human epidermal growth factor receptor 2 (HER2)-positive). She underwent targeted therapy with ado-trastuzumab emtansine every 3 weeks. Repeat PET-CT scan after 6\u2009months showed stable disease. Reassessment of receptor status in metastatic breast cancer is encouraged to rule out receptor conversion. There is significant cross-talk between OR and HER2 signalling pathways, leading to treatment resistance. Close collaboration and teamwork among various subspecialties facilitate prompt management of patients with suspected metastatic breast cancer.<\/jats:p>","DOI":"10.1136\/bcr-2021-243700","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T11:30:18Z","timestamp":1644406218000},"page":"e243700","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Receptor conversion and vocal cord paralysis in a patient with breast cancer"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-3062","authenticated-orcid":false,"given":"Harold Nathan","family":"Tan","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, University of the Philippines Manila - Philippine General Hospital, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-0227","authenticated-orcid":false,"given":"Lance Isidore Garcenila","family":"Catedral","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, University of the Philippines Manila - Philippine General Hospital, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-9623","authenticated-orcid":false,"given":"Rogelio Jr","family":"Velasco","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, University of the Philippines Manila - Philippine General Hospital, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7635-4409","authenticated-orcid":false,"given":"Michael","family":"San Juan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, University of the Philippines Manila - Philippine General Hospital, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"2025082801492536000_15.2.e243700.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2025082801492536000_15.2.e243700.2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12084"},{"key":"2025082801492536000_15.2.e243700.3","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/bjc.2015.127","article-title":"Prognosis of metastatic breast cancer: are there differences between patients with de novo and recurrent metastatic breast cancer?","volume":"112","author":"Lobbezoo","year":"2015","journal-title":"Br J Cancer"},{"key":"2025082801492536000_15.2.e243700.4","doi-asserted-by":"crossref","unstructured":"Hoefnagel LDC , van de Vijver MJ , van Slooten H-J , et al . Receptor conversion in distant breast cancer metastases. 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