{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:22:22Z","timestamp":1787062942774,"version":"build-2736575974"},"reference-count":12,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,10,28]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Diffuse large B-cell lymphoma (DLBCL) of the penis is a rare haematological malignancy, with less than 30 cases being reported in the literature. Our case mentions a 57-year-old man who presented with a penile lesion that was diagnosed as DLBCL on histological biopsy. Targeted investigation and proper diagnosis are essential to distinguish it from squamous cell carcinoma (SCC) of the glans, which presents similarly. Since guidelines are not available, the author compared different management mentioned in case reports and the outcome was noted. Chemotherapy, radiotherapy and surgery were the treatment modalities most used; out of which, chemotherapy had the most successful outcome. On the other hand, surgery is the preferred modality in SCC of the penis. This further consolidates the need for guidelines with regard to proper diagnosis and management of this malignancy.<\/jats:p>","DOI":"10.1136\/bcr-2021-243844","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T11:30:15Z","timestamp":1636716615000},"page":"e243844","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Primary high-grade diffuse large B-cell lymphoma of the glans penis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-6269","authenticated-orcid":false,"given":"Marylou","family":"Fenech","sequence":"first","affiliation":[{"name":"Haematology Department, Mater Dei Hospital, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pisani","sequence":"additional","affiliation":[{"name":"Pathology Department, Mater Dei Hospital, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David James","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Haematology Department, Mater Dei Hospital, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"2025082803272066000_14.11.e243844.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/948352","article-title":"Lymphoma presenting as cancer of the glans penis: a case report","volume":"2012","author":"Stamatiou","year":"2012","journal-title":"Case Rep Pathol"},{"key":"2025082803272066000_14.11.e243844.2","doi-asserted-by":"crossref","DOI":"10.5070\/D37GG2J8VR","article-title":"Primary cutaneous CD30+ T-cell lymphoproliferative disorder presenting as paraphimosis: a case report and review of the literature","volume":"17","author":"McNab","year":"2011","journal-title":"Dermatol Online J"},{"key":"2025082803272066000_14.11.e243844.3","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20170273","article-title":"Genitourinary involvement of lymphomas on FDG-PET","volume":"91","author":"Naik","year":"2018","journal-title":"Br J Radiol"},{"key":"2025082803272066000_14.11.e243844.4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/aja.2013.21","article-title":"Primary malignant lymphoma of the glans penis: a rare case report and review of the literature","volume":"15","author":"Chu","year":"2013","journal-title":"Asian J Androl"},{"key":"2025082803272066000_14.11.e243844.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000212951.50974.a9"},{"key":"2025082803272066000_14.11.e243844.6","doi-asserted-by":"publisher","DOI":"10.1159\/000052441"},{"key":"2025082803272066000_14.11.e243844.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67637-7"},{"key":"2025082803272066000_14.11.e243844.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80726-5"},{"key":"2025082803272066000_14.11.e243844.9","doi-asserted-by":"crossref","first-page":"929.e3","DOI":"10.1016\/j.urology.2008.04.059","article-title":"Progressive Painless Swelling of Glans Penis: Uncommon Clinical Manifestation of Systemic Non-Hodgkin\u2019s Lymphoma","volume":"73","author":"Gallardo","year":"2009","journal-title":"Urology"},{"key":"2025082803272066000_14.11.e243844.10","doi-asserted-by":"crossref","DOI":"10.5070\/D32K49P3GP","article-title":"Recurrent lymphoma presenting as a penile ulcer in a patient with AIDS","volume":"11","author":"Jabr","year":"2005","journal-title":"Dermatol Online J"},{"key":"2025082803272066000_14.11.e243844.11","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3892\/ol.2014.2488","article-title":"Priapism as the initial symptom of primary penile lymphoma: a case report","volume":"8","author":"Gong","year":"2014","journal-title":"Oncol Lett"},{"key":"2025082803272066000_14.11.e243844.12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.4274\/tjh.2016.0132","article-title":"Presentation of diffuse large B-cell lymphoma relapse as a penile mass. 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