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He did not have any surgical intervention. He was successfully treated with 6 weeks of ceftriaxone, followed by chronic suppression with oral doxycycline. Despite its low virulence, a growing number of <jats:italic>C. acnes<\/jats:italic> PVE cases have been reported, owing to its biofilm production. When clinical suspicion is high, extending culture incubation duration beyond the standard 5\u2009days might be helpful. Most cases are treated with surgical repair or replacement in conjunction with antibiotics, but medical therapy alone has been documented as being successful.<\/jats:p>","DOI":"10.1136\/bcr-2021-243878","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:53:07Z","timestamp":1627559587000},"page":"e243878","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Recurrent <i>Cutibacterium acnes<\/i> prosthetic valve endocarditis"],"prefix":"10.1136","volume":"14","author":[{"given":"Ahmed Ashraf","family":"Abdelhamid","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-4798","authenticated-orcid":false,"given":"Takaaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Tholany","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-9419","authenticated-orcid":false,"given":"Poorani","family":"Sekar","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"2025082803141487000_14.7.e243878.1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivw087"},{"key":"2025082803141487000_14.7.e243878.2","first-page":"1212","article-title":"[Propionibacterium acnes infective endocarditis. 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