{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:16:58Z","timestamp":1764260218915,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,12,23]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>A 25-year-old woman presented with cardiogenic shock following intentional overdose of Common Yew (<jats:italic>Taxus baccata<\/jats:italic>). The pharmacological mechanisms underlying yew toxicity resulted in failure of multiple treatment modalities including inotropes, vasopressors and attempted pacing. Resuscitation was ultimately unsuccessful. The limited literature available on this kind of overdose suggests that early extracorporeal membrane oxygenation (ECMO) is the mainstay of treatment in severe cases presenting with hypotension and arrhythmias. However, there may be a role for digoxin antibody fragments in maintaining patients presenting to remote sites, to allow transfer to a specialist centre.<\/jats:p>","DOI":"10.1136\/bcr-2021-243896","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T11:20:24Z","timestamp":1650021624000},"page":"e243896","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Fatal overdose of <i>Taxus baccata<\/i> plant matter treated in a rural district general hospital"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8927-5910","authenticated-orcid":false,"given":"Emma","family":"Vallis-Booth","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Queen Elizabeth Hospital King's Lynn NHS Foundation Trust, King's Lynn, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"2025082710265156000_15.4.e243896.1","unstructured":"National Center for Biotechnology Information . PubChem compound summary for CID 6433563, Taxine, 2020. Available: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Taxine [Accessed 31 Aug 2020]."},{"key":"2025082710265156000_15.4.e243896.2","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1016\/j.crvasa.2014.11.003","article-title":"Cardiotoxicity of yew","volume":"57","author":"Piska\u010d","year":"2015","journal-title":"Cor Vasa"},{"key":"2025082710265156000_15.4.e243896.3","unstructured":"National Poisons Information Services . Taxus baccata (yew), 2016. Available: https:\/\/www.toxbase.org\/Poisons-Index-A-Z\/Y-Products\/Yew\/ [Accessed 31 Aug 2020]."},{"key":"2025082710265156000_15.4.e243896.4","doi-asserted-by":"crossref","DOI":"10.1186\/1757-7241-18-51","article-title":"Intravenous lipid emulsion in clinical toxicology","volume":"18","author":"Rothschild","year":"2010","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"2025082710265156000_15.4.e243896.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)82138-9"},{"key":"2025082710265156000_15.4.e243896.6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ijcard.2014.11.221","article-title":"Prolonged resuscitation and cardiogenic shock after intoxication with European yew (Taxus baccata): Complete recovery after intermittent mechanical circulatory support","volume":"181","author":"Baum","year":"2015","journal-title":"Int J Cardiol"},{"key":"2025082710265156000_15.4.e243896.7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajem.2017.09.031","article-title":"Extracorporeal life support and digoxin-specific Fab fragments for successful management of Taxus baccata intoxication with low output and ventricular arrhythmia","volume":"35","author":"Farag","year":"2017","journal-title":"Am J Emerg Med"},{"key":"2025082710265156000_15.4.e243896.8","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr037"},{"key":"2025082710265156000_15.4.e243896.9","doi-asserted-by":"publisher","DOI":"10.1177\/0885066606290386"},{"key":"2025082710265156000_15.4.e243896.10","unstructured":"Hassan S , Goyal A . Digoxin immune fab. In: StatPearls. Treasure Island, FL: StatPearls Publishing, 2020. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK556101\/"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-243896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:26:59Z","timestamp":1756315619000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-243896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,15]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bcr-2021-243896"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-243896","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}