{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:58:27Z","timestamp":1778126307169,"version":"3.51.4"},"reference-count":8,"publisher":"BMJ","issue":"7","funder":[{"DOI":"10.13039\/501100005809","name":"Hyderabad Eye Research Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,6,16]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Corneal ocular surface squamous neoplasia usually begins at the limbus and presents as an avascular translucent sheet over the corneal surface. This case report describes a 67-year-old man with an unusual isolated, keratinous nodular corneal lesion. Slit-lamp examination showed an elevated, avascular, whitish plaque-like lesion at the central cornea surrounded by a normal corneal epithelium, with reduced visual acuity of 20\/200 in the right eye. Anterior segment optical coherence tomography displayed a hyper-reflective, thickened epithelium with back shadowing. Histopathology showed keratinising hyperplastic stratified squamous epithelium with parakeratosis and moderate nuclear pleomorphism in lower second\/third of epithelium suggestive of moderate dysplasia. His visual acuity returned to 20\/20 after surgical excision but he developed multifocal corneal recurrences 6\u2009weeks later, which were successfully managed with seven cycles of topical interferon immunotherapy. There are no recurrences observed at 6 months of follow-up.<\/jats:p>","DOI":"10.1136\/bcr-2021-243925","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T12:35:23Z","timestamp":1626093323000},"page":"e243925","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Isolated keratinising corneal ocular surface squamous neoplasia with multifocal recurrence"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7420-9438","authenticated-orcid":false,"given":"Swati","family":"Singh","sequence":"first","affiliation":[{"name":"Ophthalmic Plastic Surgery, Orbit and Ocular Oncology Services, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saumya","family":"Jakati","sequence":"additional","affiliation":[{"name":"Ophthalmic Pathology Laboratory, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Pasari","sequence":"additional","affiliation":[{"name":"Indriya Eye & ENT Hospital, Nagpur, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayan","family":"Basu","sequence":"additional","affiliation":[{"name":"The Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"2025082707125586000_14.7.e243925.1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200310000-00015"},{"key":"2025082707125586000_14.7.e243925.2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2017.01.035","article-title":"Solitary Nonvascularized corneal epithelial dysplasia","volume":"124","author":"Jeon","year":"2017","journal-title":"Ophthalmology"},{"key":"2025082707125586000_14.7.e243925.3","article-title":"A case of solitary Nonvascularized corneal epithelial dysplasia","volume":"2016","author":"Morii","year":"2016","journal-title":"Case Rep Ophthalmol Med"},{"key":"2025082707125586000_14.7.e243925.4","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-235789","article-title":"Incidentally detected primary corneal squamous neoplasia in an elderly man presenting with cataract","volume":"13","author":"Agarwal","year":"2020","journal-title":"BMJ Case Rep"},{"key":"2025082707125586000_14.7.e243925.5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S1542-0124(12)70179-9","article-title":"Corneal keloid","volume":"6","author":"Vanathi","year":"2008","journal-title":"Ocul Surf"},{"key":"2025082707125586000_14.7.e243925.6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajoc.2020.100901","article-title":"A rare case of corneal keloid occurred 30 years after pterygium surgery and 3 years after cataract surgery","volume":"20","author":"Miyamoto","year":"2020","journal-title":"Am J Ophthalmol Case Rep"},{"key":"2025082707125586000_14.7.e243925.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2015.02.001"},{"key":"2025082707125586000_14.7.e243925.8","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/ICO.0000000000001680","article-title":"High-Resolution anterior segment optical coherence tomography in intraepithelial versus invasive ocular surface squamous neoplasia","volume":"37","author":"Singh","year":"2018","journal-title":"Cornea"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-243925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:13:05Z","timestamp":1756303985000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-243925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":8,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,12]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1136\/bcr-2021-243925"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-243925","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}