{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:18:48Z","timestamp":1793992728448,"version":"4.8.0"},"reference-count":6,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,12]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>A 51-year-old woman presented with a 2-week history of off balance, left lower limb weakness and neglect and neck pain radiating down the right arm. Investigations revealed a metastatic, ROS1 fusion-positive, non-small cell lung cancer, and treatment with entrectinib, a recently approved multikinase inhibitor, was started. Two weeks after, she was admitted to the emergency department with new-onset pressure-like chest pain and dyspnoea. Laboratory evaluation showed elevated troponin and mild left ventricular systolic dysfunction with reduced global longitudinal strain on transthoracic echocardiogram. Cardiac magnetic resonance revealed mild oedema and non-ischaemic fibrosis. A diagnosis of drug-induced myocarditis was made. Cardioprotective medication with an angiotensin-converting enzyme inhibitor and a beta-blocker was started. Entrectinib was temporarily discontinued and restarted at a reduced dose after a multidisciplinary team meeting involving both the oncology and cardio-oncology teams. This is the second described case of entrectinib-induced myocarditis and the first one without eosinophilia.<\/jats:p>","DOI":"10.1136\/bcr-2021-243946","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T11:30:43Z","timestamp":1627385443000},"page":"e243946","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Entrectinib-related myocarditis in a young female patient with metastatic non-small cell lung cancer"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7656-0237","authenticated-orcid":false,"given":"Marta","family":"Fonseca","sequence":"first","affiliation":[{"name":"Saint Bartholomew's Hospital Barts Heart Centre, London, UK"},{"name":"Hatter Cardiovascular Institute, Hatter Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H","family":"Chen","sequence":"additional","affiliation":[{"name":"Saint Bartholomew's Hospital Barts Heart Centre, London, UK"},{"name":"Hatter Cardiovascular Institute, Hatter Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Malcolm","family":"Walker","sequence":"additional","affiliation":[{"name":"Hatter Cardiovascular Institute, Hatter Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun K","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Saint Bartholomew's Hospital Barts Heart Centre, London, UK"},{"name":"Hatter Cardiovascular Institute, Hatter Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"2025082703202102000_14.7.e243946.1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1470-2045(19)30690-4","article-title":"Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials","volume":"21","author":"Drilon","year":"2020","journal-title":"Lancet Oncol"},{"key":"2025082703202102000_14.7.e243946.2","unstructured":"Entrectinib for treating ROS1-positive advanced non- small-cell lung cancer, 2020. Available: https:\/\/www.nice.org.uk\/guidance\/ta643 [Accessed 20 Mar 2021]."},{"key":"2025082703202102000_14.7.e243946.3","unstructured":"Dziadziuszko R , Krebs MG , De Braud F . Updated integrated analysis of the efficacy and safety of Entrectinib in locally advanced or metastatic ROS1 Fusion\u2013Positive Non\u2013Small-Cell lung cancer. J Clin Oncol."},{"key":"2025082703202102000_14.7.e243946.4","unstructured":"ROZLYTREK FDA package insert, 2019. Available: http:\/\/www.fda.gov\/CompanionDiagnostics%0Ahttp:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/202570s002lbl.pdf [Accessed 21 Feb 2021]."},{"key":"2025082703202102000_14.7.e243946.5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.recesp.2015.10.018","article-title":"Actualizaci\u00f3n sobre miocarditis y miocardiopat\u00eda inflamatoria: el resurgir de la biopsia endomioc\u00e1rdica","volume":"69","author":"Dominguez","year":"2016","journal-title":"Rev Espa\u00f1ola Cardiol"},{"key":"2025082703202102000_14.7.e243946.6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht210"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-243946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:20:29Z","timestamp":1756290029000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-243946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":6,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,27]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1136\/bcr-2021-243946"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-243946","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}