{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:36Z","timestamp":1756339536251,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,27]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>We describe a case with complex Descemet membrane detachment (DMD) which persisted despite initial two failed surgical attempts to appose the ocular tissues. However, over time, tissue alignment was obtained spontaneously. A 60-year-old woman, operated trabeculectomy, had a total DMD intraoperatively during a complicated cataract surgery. Initial attempt to DM repositioning with intracameral air injection failed. Anterior Segment Optical Coherence Tomography (ASOCT) showed detachment of both DM and pre-Descemet\u2019s layer (PDL). After consultation with a corneal surgeon, patient was again attempted for Intra-operative Optical Coherence Tomography (iOCT)-guided settlement of DMD with intracameral air which again failed. So, the patient was registered for lamellar corneal transplant, but at 3 months follow-up, DM had spontaneously attached, confirmed on ASOCT. This case shows for the first time that even complex DMDs involving PDL, can spontaneously appose despite failed surgical interventions.<\/jats:p>","DOI":"10.1136\/bcr-2021-243960","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T12:55:58Z","timestamp":1628859358000},"page":"e243960","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous attachment of complex Descemet\u2019s membrane detachment following multiple failed interventions"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-3651","authenticated-orcid":false,"given":"Shikha","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-825X","authenticated-orcid":false,"given":"Karthikeyan","family":"Mahalingam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"2025082709414883000_14.8.e243960.1","unstructured":"Carrington H . Fasting for health and long life. In: Health research books, 1996."},{"key":"2025082709414883000_14.8.e243960.2","unstructured":"Ryan SJ , Schachat AP , Wilkinson CP . Ryan\u2019s Retina. 6th edn. Elsevier Health Sciences, 01 Nov 2012: 1668."},{"key":"2025082709414883000_14.8.e243960.3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mehy.2012.09.015","article-title":"Auto-descemet membrane endothelial keratopalsty (auto-DMEK)","volume":"80","author":"Agarwal","year":"2013","journal-title":"Med Hypotheses"},{"key":"2025082709414883000_14.8.e243960.4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3928\/01913913-20190405-01","article-title":"A membrane in the eye","volume":"56","author":"Gupta","year":"2019","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"2025082709414883000_14.8.e243960.5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/ICL.0000000000000235","article-title":"Evaluation of autograft characteristics after pterygium excision surgery: autologous blood coagulum versus fibrin glue","volume":"43","author":"Mittal","year":"2017","journal-title":"Eye Contact Lens"},{"key":"2025082709414883000_14.8.e243960.6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/ICU.0000000000000332","article-title":"Descemet membrane detachment during cataract surgery: etiology and management","volume":"28","author":"Benatti","year":"2017","journal-title":"Curr Opin Ophthalmol"},{"key":"2025082709414883000_14.8.e243960.7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ajo.2020.05.038","article-title":"\"Descemet membrane detachment\": a novel concept in diagnosis and classification","volume":"218","author":"Dua","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"2025082709414883000_14.8.e243960.8","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0886-3350(01)01220-2","article-title":"Late spontaneous resolution of a massive detachment of Descemet's membrane after phacoemulsification","volume":"28","author":"Iradier","year":"2002","journal-title":"J Cataract Refract Surg"},{"key":"2025082709414883000_14.8.e243960.9","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1097\/ICO.0b013e318197eef1","article-title":"Delayed, bilateral Descemet's membrane detachments with spontaneous resolution: implications for nonsurgical treatment","volume":"28","author":"Couch","year":"2009","journal-title":"Cornea"},{"key":"2025082709414883000_14.8.e243960.10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.survophthal.2017.07.004","article-title":"A review of the evidence for in-vivo corneal endothelial regeneration","volume":"63","author":"Van den Bogerd","year":"2018","journal-title":"Surv Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-243960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:41:54Z","timestamp":1756312914000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-243960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,13]]},"published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1136\/bcr-2021-243960"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-243960","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}