{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:21:00Z","timestamp":1767666060711,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,9,21]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>We report a case of a 60-year-old man who struggled with frequent migraines for 12.5 years, which were refractory to all conventional therapies. Six months before initial consultation, these migraines become chronic. The patient was then advised to follow the Low Inflammatory Foods Everyday (LIFE) diet, a nutrient-dense, dark green leafy vegetable-rich, whole food plant-based diet. Within 2 months, his headache frequency declined from 18 to 24 headache days per month to 1, and he discontinued his preventive and abortive migraine medications. After 3 months, the patient had no headaches. These results far exceed the goal of migraine treatment with medication, which is to reduce migraine frequency by &gt;50% per month. In addition, the results were durable; this patient has been migraine-free for 7.5 years. Serum beta-carotene more than tripled after the patient started the LIFE diet, consistent with its high content of dark green leafy vegetables. Weight, high-sensitivity C-reactive protein (hsCRP), complete blood count (CBC), hydration status, sodium and other electrolytes remained constant throughout the study.<\/jats:p>","DOI":"10.1136\/bcr-2021-243987","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T20:00:22Z","timestamp":1637265622000},"page":"e243987","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Chronic migraine reversal and prevention with the LIFE diet: a nutrient dense whole food plant-based diet (WFPBD)"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0528-5247","authenticated-orcid":false,"given":"Brittany Marie","family":"Perzia","sequence":"first","affiliation":[{"name":"Stony Brook University Health Sciences Center School of Medicine, Stony Brook, Long Island, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua L","family":"Dunaief","sequence":"additional","affiliation":[{"name":"Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Dunaief","sequence":"additional","affiliation":[{"name":"Private Practice, East Setauket, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"2025082709364296000_14.12.e243987.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"2025082709364296000_14.12.e243987.2","first-page":"1","volume-title":"The International classification of headache disorders","volume":"38","year":"2018"},{"key":"2025082709364296000_14.12.e243987.3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1212\/CON.0000000000000199","article-title":"Preventive migraine treatment","volume":"21","author":"Silberstein","year":"2015","journal-title":"Continuum"},{"key":"2025082709364296000_14.12.e243987.4","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-69"},{"key":"2025082709364296000_14.12.e243987.5","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9020116","article-title":"The use of antioxidants in the treatment of migraine","volume":"9","author":"Goschorska","year":"2020","journal-title":"Antioxidants"},{"key":"2025082709364296000_14.12.e243987.6","first-page":"205","article-title":"Interaction of oxygen and oxy-radicals with carotenoids","volume":"69","author":"Krinsky","year":"1982","journal-title":"J Natl Cancer Inst"},{"key":"2025082709364296000_14.12.e243987.7","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.15.1903"},{"key":"2025082709364296000_14.12.e243987.8","doi-asserted-by":"crossref","unstructured":"Hannah Schultz B , Ying G-S , PhD JLD . Md. rising plasma beta-carotene is associated with diminishing C-reactive protein in patients consuming a dark leafy Vegetable\u2013Rich, low inflammatory foods everyday (life) diet. American Journal of Lifestyle Medicine 2019.","DOI":"10.1177\/1559827619894954"},{"key":"2025082709364296000_14.12.e243987.9","doi-asserted-by":"crossref","unstructured":"Perzia B YG-S , Dunaief JL , Dunaief DM . Once-daily low inflammatory foods everyday (life) Smoothie or the full life diet lowers C-reactive protein and raises plasma beta-carotene in 7 days. 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