{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:04:36Z","timestamp":1787195076513,"version":"build-2736575974"},"reference-count":29,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,8,8]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Since identified in December 2019, COVID-19 has remained a pandemic across the globe. Although primarily a respiratory illness, the impact of COVID-19 on other end organs has been increasingly identified. The effect of COVID-19 on the liver has yet to be completely understood. We describe a case of COVID-19 leading to end-stage cholangiopathy and deceased donor liver transplantation (LT). A 64-year-old man with no underlying respiratory or liver disease presented with acute respiratory distress secondary to COVID-19 pneumonia requiring intubation. Several months after resolution of his respiratory symptoms, he developed transaminitis, worsening jaundice, abdominal pain and dark-coloured urine. Hepatic function remained severely impaired warranting LT 259 days following his initial COVID-19 diagnosis. Explant pathology demonstrated diffuse hepatic injury, onion skinning of the bile ducts and bile duct loss in scattered portal tracts. As more patients develop COVID-19-related complications, we suggest LT as an option for COVID-19-related end-stage liver disease.<\/jats:p>","DOI":"10.1136\/bcr-2021-244168","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T12:45:49Z","timestamp":1629981949000},"page":"e244168","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Liver transplantation for post-COVID-19 sclerosing cholangitis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-1078","authenticated-orcid":false,"given":"Angela","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, Washington University in St Louis School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-3523","authenticated-orcid":false,"given":"Alexander N","family":"Wein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria B Majella","family":"Doyle","sequence":"additional","affiliation":[{"name":"Section of Abdominal Organ Transplant, Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C","family":"Chapman","sequence":"additional","affiliation":[{"name":"Section of Abdominal Organ Transplant, Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"2025082711194745000_14.8.e244168.1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.14309\/ajg.0000000000001264","article-title":"Cholangiopathy after severe COVID-19: clinical features and prognostic implications","volume":"116","author":"Faruqui","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"2025082711194745000_14.8.e244168.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2020.10.001"},{"key":"2025082711194745000_14.8.e244168.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14218\/JCTH.2020.00046","article-title":"Characteristics and mechanism of liver injury in 2019 coronavirus disease","volume":"8","author":"Li","year":"2020","journal-title":"J Clin Transl Hepatol"},{"key":"2025082711194745000_14.8.e244168.4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejim.2020.05.035","article-title":"Hepatic consequences of COVID-19 infection. 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