{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:18:38Z","timestamp":1785212318259,"version":"3.55.0"},"reference-count":14,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,8,17]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Leiomyosarcoma is a rare aggressive malignant mesenchymal tumour, accounting for 1% of all uterine malignancies. It spreads rapidly through the intraperitoneal and haematogenous pathways. It is often diagnosed postoperatively following myomectomy, hysterectomy or supracervical hysterectomy for presumed benign disease. It has a predilection for perimenopausal women with a median age of 50 years. Individuals may describe symptoms of vaginal or abdominal pressure. Physical examination may reveal a large palpable pelvic mass, which may haemorrhage. Surgery remains the mainstay of treatment. Hysterectomy and a bilateral salpingo-oophorectomy may be considered, depending on the individual\u2019s menopausal status. Ovarian preservation can be considered in young patients. Adjuvant systemic treatment and radiotherapy are of no benefit. Gemcitabine\/docetaxel and doxorubicin have shown benefit in the treatment of advanced or recurrent disease. The authors present the case of a 44-year-old woman with lower abdominal pain, vaginal bleeding and a uterine fibroid. Laboratory investigations confirmed a leucocytosis, neutrophilia and a thrombocythaemia. Further investigation with an MRI pelvis showed a very large, heterogeneous, malignant appearing pelvic mass compressing the right ureter and it appeared uterine in nature. Her staging CT showed multiple lung metastases. The diagnosis of uterine leiomyosarcoma was subsequently established. Due to the aggressive behaviour of this sarcoma subtype, novel early detection strategies and targeted therapies are required.<\/jats:p>","DOI":"10.1136\/bcr-2021-244233","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T13:10:29Z","timestamp":1629897029000},"page":"e244233","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Uterine leiomyosarcoma: a rare clinical entity"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-415X","authenticated-orcid":false,"given":"Louise","family":"Dunphy","sequence":"first","affiliation":[{"name":"Department of Surgery, Royal Berkshire NHS Foundation Trust, Reading, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Liverpool Women's Hospital, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"2025082709215329000_14.8.e244233.1","first-page":"S105","article-title":"Uterine sarcomas","volume":"131 Suppl 2","author":"Prat","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"2025082709215329000_14.8.e244233.2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0090-8258(03)00137-9","article-title":"Retrospective review of 208 patients with leiomyosarcoma of the uterus: prognostic indicators, surgical management, and adjuvant therapy","volume":"89","author":"Giuntoli","year":"2003","journal-title":"Gynecol Oncol"},{"key":"2025082709215329000_14.8.e244233.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.12.008"},{"key":"2025082709215329000_14.8.e244233.4","unstructured":"Oliva E , Carcangiu ML , Carinelli SG , et al . Mesenchymal tumours [chapter 5: tumours of the uterine corpus]. In: WHO classification of tumours of female reproductive organs. 4th edn. Lyon: IARC, 2014: 135\u201347."},{"key":"2025082709215329000_14.8.e244233.5","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199001000-00001"},{"key":"2025082709215329000_14.8.e244233.6","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21798"},{"key":"2025082709215329000_14.8.e244233.7","unstructured":"K\u00f6hler G , Belau A , Krichbaum J . Deutsches klinisches Kompetenzzentrum f\u00fcr genitale sarkome und mischtumoren an der universit\u00e4tsmedizin greifswald [DKMS] und kooperationspartner VAAO deutschland und FK Frankfurt\/Sachsenhausen. In: Datenbank und Promotionsgruppe genitale Sarkome Greifswald, 2015."},{"key":"2025082709215329000_14.8.e244233.8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ygyno.2017.02.019","article-title":"Uterine leiomyosarcoma: epidemiology, contemporary treatment strategies and the impact of uterine morcellation","volume":"145","author":"Ricci","year":"2017","journal-title":"Gynecol Oncol"},{"key":"2025082709215329000_14.8.e244233.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.01.019"},{"key":"2025082709215329000_14.8.e244233.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.019"},{"key":"2025082709215329000_14.8.e244233.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.11.023"},{"key":"2025082709215329000_14.8.e244233.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60651-5"},{"key":"2025082709215329000_14.8.e244233.13","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1080\/17512433.2017.1324295","article-title":"Olaratumab for advanced soft tissue sarcoma","volume":"10","author":"Tobias","year":"2017","journal-title":"Expert Rev Clin Pharmacol"},{"key":"2025082709215329000_14.8.e244233.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.03.018"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-244233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:22:11Z","timestamp":1756311731000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-244233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":14,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,25]]},"published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1136\/bcr-2021-244233"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-244233","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}