{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:09:31Z","timestamp":1767139771931,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"8","funder":[{"DOI":"10.13039\/501100005809","name":"Hyderabad Eye Research Foundation","doi-asserted-by":"publisher","award":["LEC-11-18-176"],"award-info":[{"award-number":["LEC-11-18-176"]}],"id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,8,2]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>The purpose of this report is to highlight the early clinical signs and management of ocular surface neoplasia following penetrating keratoplasty in xeroderma pigmentosa. A 14-year-old girl reported increased conjunctival hyperemia, tearing, photophobia in the right eye at 6 months after penetrating keratoplasty that worsened rapidly over the subsequent 2 weeks. Slit lamp examination showed increased vascularity, epithelial haze and raised whitish lesions at the graft\u2013host junction. Alcohol keratoepithelectomy was performed for confirming the diagnosis. Histology of the sample revealed severe dysplasia. The lesion resolved after surface plaque brachytherapy. The graft clarity was restored and maintained until the last follow-up of 15 months following brachytherapy. Exacerbated symptoms and clinical signs of increased vascularisation and epithelial lesions should arouse the suspicion of ocular surface neoplasia in grafted eyes. Early diagnosis and management can salvage the graft clarity.<\/jats:p>","DOI":"10.1136\/bcr-2021-244322","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T13:00:36Z","timestamp":1628686836000},"page":"e244322","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical clues to the early diagnosis and management of ocular surface neoplasia following keratoplasty in xeroderma pigmentosa"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-0024","authenticated-orcid":false,"given":"Sunita","family":"Chaurasia","sequence":"first","affiliation":[{"name":"The Cornea Institute, LV Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilip Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Ophthalmic Pathology Services, LV Prasad Eye Institute, Hyderabad, Telangana, 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