{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:48Z","timestamp":1756425828271,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,9,25]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Liver involvement in Graves\u2019 disease can be seen as a part of autoimmune process or rarely, due to the direct effects of thyrotoxicosis on liver. Hyperthyroidism can also have gastrointestinal manifestations like frequent bowel movements, diarrhoea, even malabsorption with steatorrhoea. We report a 36-year-old man with hyperthyroidism, presenting with cholestatic jaundice and persistent small bowel diarrhoea. He was diagnosed to have Graves\u2019 disease and after ruling out more common causes, the cause of cholestatic jaundice was supposed to be Graves\u2019 disease. Considering this possibility, the patient was started on treatment with carbimazole. As patient\u2019s thyroid function tests started improving, he showed significant clinical and biochemical improvement from liver point of view as well.<\/jats:p>","DOI":"10.1136\/bcr-2021-244367","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T11:27:02Z","timestamp":1636457222000},"page":"e244367","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Graves\u2019 disease associated with cholestatic jaundice and persistent diarrhoea"],"prefix":"10.1136","volume":"14","author":[{"given":"Siddhesh Vijay","family":"Rane","sequence":"first","affiliation":[{"name":"Gastroenterology, Topiwala National Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Thanage","sequence":"additional","affiliation":[{"name":"Gastroenterology, Topiwala National Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Chandnani","sequence":"additional","affiliation":[{"name":"Gastroenterology, Topiwala National Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravin M","family":"Rathi","sequence":"additional","affiliation":[{"name":"Gastroenterology, Topiwala National Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"2025082802215069000_14.11.e244367.1","doi-asserted-by":"crossref","DOI":"10.1186\/1752-1947-2-116","article-title":"Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports","volume":"2","author":"Soylu","year":"2008","journal-title":"J Med Case 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