{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:10:05Z","timestamp":1756311005711,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,10,10]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>We discuss an extremely rare case of low-grade Schwann cell leptomeningeal neoplasm with no evident intradural primary, presenting with rapid neurological decline leading to death reflecting the aggressive biological behaviour of this entity despite its low-grade morphology. Notwithstanding extensive investigations, the diagnosis was only established on autopsy as clinical presentation is non-specific making diagnosis challenging. This condition could be considered in patients presenting with leptomeningeal disease if initial workup of more common causes is non-revealing.<\/jats:p>","DOI":"10.1136\/bcr-2021-244440","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T10:36:11Z","timestamp":1637318171000},"page":"e244440","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Primary leptomeningeal low-grade Schwann cell neoplasm"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5548-7501","authenticated-orcid":false,"given":"Wilson","family":"Vallat","sequence":"first","affiliation":[{"name":"Neurology, Lyell McEwin Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siby","family":"Antony","sequence":"additional","affiliation":[{"name":"Medicine, Lyell McEwin Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"McLean","sequence":"additional","affiliation":[{"name":"Anatomical Pathology, Alfred Health, Prahan, Victoria, Australia"},{"name":"Victorian Brain Bank, The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"2025082708540086000_14.11.e244440.1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.humpath.2016.08.010","article-title":"Low-grade Schwann cell neoplasms with leptomeningeal dissemination: clinicopathologic and autopsy findings","volume":"60","author":"Rodriguez","year":"2017","journal-title":"Hum Pathol"},{"key":"2025082708540086000_14.11.e244440.2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3171\/2014.4.SPINE13739","article-title":"Primary malignant peripheral nerve sheath tumor of the spine with acute hydrocephalus: a rare clinical entity","volume":"21","author":"Li","year":"2014","journal-title":"J Neurosurg Spine"},{"key":"2025082708540086000_14.11.e244440.3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s002340050538","article-title":"Ossified retroperitoneal malignant schwannoma with spinal leptomeningeal metastases","volume":"40","author":"Mortel\u00e9","year":"1998","journal-title":"Neuroradiology"},{"key":"2025082708540086000_14.11.e244440.4","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.jocn.2012.09.039","article-title":"Leptomeningeal metastasis of an intradural malignant peripheral nerve sheath tumor","volume":"20","author":"Stark","year":"2013","journal-title":"J Clin Neurosci"},{"key":"2025082708540086000_14.11.e244440.5","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3171\/2014.7.SPINE13802","article-title":"Radiation-Induced intradural malignant peripheral nerve sheath tumor of the cauda equina with diffuse leptomeningeal metastasis","volume":"21","author":"Lau","year":"2014","journal-title":"J Neurosurg Spine"},{"key":"2025082708540086000_14.11.e244440.6","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20272"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-244440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:54:08Z","timestamp":1756310048000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-244440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":6,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,19]]},"published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1136\/bcr-2021-244440"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-244440","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,11]]}}}