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After serial \u03b2-human chorionic gonadotropin levels and ultrasound confirmation of a viable pregnancy 23 days later, the patient underwent a normal antenatal course and delivered a healthy infant at 37 weeks gestation. This unusual case highlights the need to consider spontaneous haemoperitoneum in pregnancy as a diagnosis, particularly in the setting of pregnancy of unknown location, even at an early stage of pregnancy.<\/jats:p>","DOI":"10.1136\/bcr-2021-244470","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T17:10:28Z","timestamp":1631466628000},"page":"e244470","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Idiopathic spontaneous haemoperitoneum at 4 weeks gestation"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6879-5063","authenticated-orcid":false,"given":"Emily","family":"O'Brien","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA"},{"name":"Penn State College of Medicine, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-1035","authenticated-orcid":false,"given":"Rehan","family":"Feroz","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6201-0242","authenticated-orcid":false,"given":"Sona","family":"Jasani","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082708032135000_14.9.e244470.1","DOI":"10.1067\/j.cpradiol.2005.06.001"},{"key":"2025082708032135000_14.9.e244470.2","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20200383","article-title":"Identifying corpus luteum rupture as the culprit for haemoperitoneum","volume":"94","author":"Pulappadi","year":"2021","journal-title":"Br J Radiol"},{"key":"2025082708032135000_14.9.e244470.3","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.fertnstert.2016.05.025","article-title":"Severe spontaneous hemoperitoneum in pregnancy may be linked to in\u00a0vitro fertilization in patients with endometriosis: a systematic review","volume":"106","author":"Brosens","year":"2016","journal-title":"Fertil Steril"},{"doi-asserted-by":"publisher","key":"2025082708032135000_14.9.e244470.4","DOI":"10.1093\/humrep\/"},{"key":"2025082708032135000_14.9.e244470.5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.fertnstert.2017.10.035","article-title":"Obstetrical complications of endometriosis, particularly deep endometriosis","volume":"108","author":"Leone Roberti Maggiore","year":"2017","journal-title":"Fertil Steril"},{"key":"2025082708032135000_14.9.e244470.6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejogrb.2017.10.012","article-title":"Spontaneous hemoperitoneum in pregnancy (SHiP) and endometriosis - a systematic review of the recent literature","volume":"219","author":"Lier","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"doi-asserted-by":"publisher","key":"2025082708032135000_14.9.e244470.7","DOI":"10.1016\/j.fertnstert.2009.03.091"},{"key":"2025082708032135000_14.9.e244470.8","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1001\/jama.2013.3914","article-title":"Does this woman have an ectopic pregnancy?: the rational clinical examination systematic review","volume":"309","author":"Crochet","year":"2013","journal-title":"JAMA"},{"key":"2025082708032135000_14.9.e244470.9","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1097\/AOG.0000000000002560","article-title":"ACOG practice Bulletin No. 193: tubal ectopic pregnancy","volume":"131","year":"2018","journal-title":"Obstet Gynecol"},{"key":"2025082708032135000_14.9.e244470.10","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1097\/AOG.0000000000004124","article-title":"Prioritizing Desiredness in pregnancy of unknown location: an algorithm for patient-centered care","volume":"136","author":"Flynn","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2025082708032135000_14.9.e244470.11","doi-asserted-by":"crossref","DOI":"10.1097\/01.AOG.0000483372.49239.1c","article-title":"Is There a Consensus Regarding Management of a Pregnancy of Unknown Location? 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