{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:40:21Z","timestamp":1756291221612,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,10,30]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Secondary central nervous system lymphoma is rare, occurring in up to 10% of non-Hodgkin's lymphoma patients and in 5% of diffuse large B-cell lymphoma patients. The prognosis is poor, even rarer is metastasis of large B-cell lymphomas into Meckel\u2019s cave and the trigeminal nerve roots. We describe a relapsing case of a large B-cell lymphoma that migrated into Meckel\u2019s cave, the mandibular branch of the trigeminal nerve and the adjacent cavernous sinus. We review petrous apex anatomy, review the literature of metastatic spread into Meckel\u2019s cave and analyse existing pathoanatomical studies that explain the conduits and barriers of tumour spread. Understanding this pathoanatomical relationship is critical for neurologists and neurosurgeons alike to effectively correlate patient signs and symptoms to intracranial pathology and identify origins and sites of metastatic dispersion in similar rare clinical scenarios.<\/jats:p>","DOI":"10.1136\/bcr-2021-244512","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T07:15:27Z","timestamp":1636614927000},"page":"e244512","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Malignant lymphomatous invasion of Meckel\u2019s cave: pathoanatomical considerations of the petrous apex"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0852-2327","authenticated-orcid":false,"given":"Dario Alfredo","family":"Marotta","sequence":"first","affiliation":[{"name":"Department of Research, Alabama College of Osteopathic Medicine, Dothan, Alabama, USA"},{"name":"Department of Neurology, Division of Neuropsychology, The University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Research, Alabama College of Osteopathic Medicine, Dothan, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Cohen-Gadol","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, Indiana, USA"},{"name":"The Neurosurgical Atlas, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Kesserwani","sequence":"additional","affiliation":[{"name":"Dothan Neurology, Dothan, Alabama, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"2025082703110229000_14.11.e244512.1","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.4067\/S0717-95022013000400047","article-title":"Trigeminal cave and ganglion: an anatomical review","volume":"31","author":"Ajayi","year":"2013","journal-title":"Int. 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Morphol."},{"key":"2025082703110229000_14.11.e244512.2","first-page":"1317","article-title":"MR imaging of the trigeminal ganglion, nerve, and the perineural vascular plexus: normal appearance and variants with correlation to cadaver specimens","volume":"24","author":"Williams","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025082703110229000_14.11.e244512.3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF00327603","article-title":"High resolution CT of Meckel's cave","volume":"27","author":"Chui","year":"1985","journal-title":"Neuroradiology"},{"key":"2025082703110229000_14.11.e244512.4","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.151.3.577"},{"key":"2025082703110229000_14.11.e244512.5","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-018-0604-7"},{"key":"2025082703110229000_14.11.e244512.6","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V124.21.5389.5389","article-title":"Clinical features, treatment, and survival of secondary central nervous system lymphoma","volume":"124","author":"Herr","year":"2014","journal-title":"Blood"},{"key":"2025082703110229000_14.11.e244512.7","unstructured":"Anterior Petrosectomy [Internet]. 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